Further model studies related to fredericamycin A: Analogues in which ring C is expanded to six atoms, and an examination of the diastereoselectivity of radical spirocyclization

被引：24
作者：
Clive, DLJ
Kong, XL
Paul, CC
机构：
[1] Chemistry Department, University of Alberta, Edmonton
来源：
TETRAHEDRON | 1996年 / 52卷 / 17期
基金：
加拿大自然科学与工程研究理事会;
关键词：
D O I：
10.1016/0040-4020(96)00245-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The fredericamycin A analogues 5 and 23 were synthesized. A key step is the process of radical spirocyclization, and the diastereoselectivity of this reaction was studied with model compounds. In vitro tests showed that 23 was active against certain cell lines of colon and prostate cancer, while compound 5 was essentially inactive. (C) 1996 Elsevier Science Ltd.
引用
收藏
页码：6085 / 6116
页数：32
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