Formal Synthesis of Nitidine and Nk109 via Palladium-Catalyzed Domino Direct Arylation/N-Arylation of Aryl Triflates

被引：124
|
作者：
Blanchot, Mathieu [1 ]
Candito, David A. [1 ]
Larnaud, Florent [1 ]
Lautens, Mark [1 ]
机构：
[1] Univ Toronto, Davenport Res Labs, Dept Chem, Toronto, ON M5S 3H6, Canada
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 06期
基金：
加拿大自然科学与工程研究理事会;
关键词：
TOPOISOMERASE-I; BOND FORMATION; FORMING REACTIONS; CONCISE SYNTHESIS; N-ARYLATION; PHENANTHRIDINES; ALKALOIDS; 12-METHOXYDIHYDROCHELERYTHRINE; CYCLIZATION; ANNULATION;
D O I：
10.1021/ol200174g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The use of aryl triflates as reaction partners in a palladium-catalyzed domino direct arylation/N-arylation provides a great advantage due to the availability of starting materials. Furthermore, it allows expedient access to biologically Interesting benzo[c]phenanthridine alkaloids.
引用
收藏
页码：1486 / 1489
页数：4
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