Efficiency of iloprost treatment for osseous malperfusion

被引：39

作者：

Jaeger, Marcus ^{[1
]}

Zilkens, Christoph ^{[1
]}

Bittersohl, Bernd ^{[1
]}

Matheney, Travis ^{[2
]}

Kozina, Gordana ^{[1
]}

Blondin, Dirk ^{[3
]}

Krauspe, Ruediger ^{[1
]}

机构：

[1] Univ Hosp Duesseldorf, Dept Orthopaed Surg, Dusseldorf, Germany

[2] Childrens Hosp, Dept Orthoped Surg, Boston, MA 02115 USA

[3] Univ Hosp Duesseldorf, Dept Radiol, Dusseldorf, Germany

来源：

INTERNATIONAL ORTHOPAEDICS | 2011年 / 35卷 / 05期

关键词：

BONE-MARROW-EDEMA; PROSTACYCLIN ANALOG ILOPROST; FEMORAL-HEAD; AVASCULAR NECROSIS; INTRAVENOUS ILOPROST; ASEPTIC OSTEONECROSIS; CHEMOTHERAPY; MANAGEMENT; CHILDHOOD; JUVENILE;

D O I：

10.1007/s00264-010-0998-4

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Insufficient osseous blood supply results in bone marrow oedema (BMO) and/or avascular necrosis (AVN). One treatment option to support osseous perfusion is the application of stable prostacycline analog iloprost. In this clinical study, 95 patients were treated with iloprost for BMO/AVN. One hundred eighty-six bones were affected by BMO/AVN before treatment. Average follow-up was 33.0 +/- 17.6 months. Pain levels could be reduced (e.g. visual analogue scale, 5.0 +/- 2.2 points reduced to 1.7 +/- 2.2 points) and functional scores improved (Harris hip score, 52 +/- 21 points to 79 +/- 17 points) in the course of treatment. According to current data, healing of advanced stages of osteonecrosis is not possible. However, the results of this case series confirm previous findings that in early stages of insufficient osseous blood flow iloprost can contribute to the relief of pain and improve joint function.

引用

页码：761 / 765

页数：5

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