NMR in structure-based drug design

被引：8
作者：
Carneiro, Marta G. [1 ]
Eiso, A. B. [1 ]
Theisgen, Stephan [1 ]
Siegal, Gregg [1 ]
机构：
[1] ZoBio, JH Oortweg 19, NL-2333 CH Leiden, Netherlands
来源：
STRUCTURE-BASED DRUG DESIGN: INSIGHTS FROM ACADEMIA AND INDUSTRY | 2017年 / 61卷 / 05期
关键词：
INTRINSICALLY DISORDERED PROTEINS; AUTOMATED RESONANCE ASSIGNMENT; CHEMICAL-SHIFT; CONFORMATIONAL-CHANGES; LIGAND COMPLEXES; BINDING-SITES; 3D STRUCTURE; IDENTIFICATION; SPECTROSCOPY; INHIBITORS;
D O I：
10.1042/EBC20170037
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
NMR spectroscopy is a powerful technique that can provide valuable structural information for drug discovery endeavors. Here, we discuss the strengths (and limitations) of NMR applications to structure-based drug discovery, highlighting the different levels of resolution and throughput obtainable. Additionally, the emerging field of paramagnetic NMR in drug discovery and recent developments in approaches to speed up and automate protein-observed NMR data collection and analysis are discussed.
引用
收藏
页码：485 / 493
页数：9
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