18F-FDG PET can replace conventional work-up in primary M staging of nonkeratinizing nasopharyngeal carcinoma

被引：70

作者：

Liu, Feng-Yuan ^{[1
,2
]}

Lin, Chien-Yu ^{[3
]}

Chang, Joseph T. ^{[3
]}

Ng, Shu-Hang ^{[4
]}

Chin, Shy-Chyi ^{[4
]}

Wang, Hung-Ming ^{[5
]}

Liao, Chun-Ta ^{[6
]}

Chan, Sheng-Chieh ^{[1
,2
]}

Yen, Tzu-Chen ^{[1
,2
]}

机构：

[1] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Nucl Med, Taipei 10507, Taiwan

[2] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Mol Imaging Ctr, Taipei 10507, Taiwan

[3] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Radiat Oncol, Taipei, Taiwan

[4] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Diagnost Radiol, Taipei, Taiwan

[5] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Div Hematol Oncol,Dept Internal Med, Taipei, Taiwan

[6] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp, Dept Otorhinolaryngol, Taipei, Taiwan

来源：

JOURNAL OF NUCLEAR MEDICINE | 2007年 / 48卷 / 10期

关键词：

F-18-FDG PET; nasopharyngeal carcinoma; staging; distant metastasis;

D O I：

10.2967/jnumed.107.043406

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Conventional work-up (CWU) with chest radiography, abdominal ultrasonography, and skeletal scintigraphy has limited value in M staging of nonkeratinizing nasopharyngeal carcinoma (NPC). Our aim was to evaluate whether F-18-FDG PET could replace CWU by comparing their diagnostic efficacies. Methods: Patients with histologically proven nonkeratinizing NPC and no prior treatment were prospectively enrolled. All study participants underwent CWU and F-18-FDG PET for primary M staging. Distant metastasis was considered to be present if there was any reliable evidence identified within 1 y after diagnosis. The comparative diagnostic efficacies of F-18-FDG PET, CWU, and the combination of F-18-FDG PET and CWU (PET+CWU) were evaluated using the areas under the receiver-operating-characteristic (ROC) curves. Results: Sixty-one (20.3%) of 300 eligible patients were found to have distant metastases. On a patient-based analysis, 18F-FDG PET was found to be more effective than CWU (P < 0.001), whereas it was equally effective with PET+CWU (P = 0.130). On region-based analyses, F-18-FDG PET was more effective than skeletal scintigraphy and chest radiography for detecting bone metastases (P < 0.001) and chest metastases (P < 0.001), respectively. F-18-FDG PET and abdominal ultrasound were equally effective for detecting hepatic metastases (P = 0.127). On region-based analyses, the combination of F-18-FDG PET and CWU did not yield any noticeable increase in diagnostic efficacy. Conclusion: F-18-FDG PET can replace CWU in primary M staging of nonkeratinizing NPC.

引用

页码：1614 / 1619

页数：6

共 23 条

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