No clinical significance of the time interval between biopsy and robotic-assisted radical prostatectomy for patients with clinically localized prostate cancer on biochemical recurrence: a propensity score matching analysis

被引：8

作者：

Hirasawa, Yosuke ^{[1
]}

Ohori, Makoto ^{[1
]}

Sugihara, Toru ^{[1
]}

Hashimoto, Takeshi ^{[1
]}

Satake, Naoya ^{[1
]}

Gondo, Tatsuo ^{[1
]}

Nakagami, Yoshihiro ^{[1
]}

Namiki, Kazunori ^{[1
]}

Yoshioka, Kunihiko ^{[2
]}

Nakashima, Jun ^{[3
]}

Tachibana, Masaaki ^{[1
]}

Ohno, Yoshio ^{[1
]}

机构：

[1] Tokyo Med Univ, Dept Urol, Tokyo, Japan

[2] SHIN YURIGAOKA Gen Hosp, Dept Urol, Kanagawa, Japan

[3] Sanno Hosp, Dept Urol, Tokyo, Japan

来源：

JAPANESE JOURNAL OF CLINICAL ONCOLOGY | 2017年 / 47卷 / 11期

关键词：

prostate cancer; robot-assisted radical prostatectomy; propensity score matching analysis; time interval; biopsy; biochemical recurrence; ACTIVE SURVEILLANCE; RADIATION-THERAPY; BREAST-CANCER; DELAY; MEN; RISK; DIAGNOSIS; OUTCOMES; IMPACT; STAGE;

D O I：

10.1093/jjco/hyx125

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

To investigate the impact of the time interval (TI) between prostate biopsy and robot-assisted radical prostatectomy (RARP) on the risk of biochemical recurrence (BCR). We retrospectively reviewed the medical records of 793 consecutive patients who were treated with RARP at our institution. Patients were divided into three groups, according to TI, to compare BCR-free survival (BCRFS) rates: Group 1 (n = 196), TI < 3 months; Group 2 (n = 513), 3 <= TI < 6 months; Group 3 (n = 84), TI >= 6 months. Eighty-three patients with TI >= 6 months were matched with an equal number of patients with TI < 6 months based on propensity scores by using four preoperative factors: prostate-specific antigen (PSA), primary (pGS) and secondary (sGS) Gleason score and positive prostate biopsy. The 5-year BCRFS rates for TI Groups 1, 2, and 3 were 76%, 80.7% and 82.6% (P = 0.99), respectively. The multivariate analysis revealed that PSA, pGS, sGS and a positive prostate biopsy were independent preoperative risk factors for BCR. The propensity adjusted 5-year BCRFS for patients with TI >= 6 months was 84.0%. This was not worse than that of patients with TI < 6 months (71.0%, P = 0.18). In our cohorts, a delay in the time from biopsy to RARP did not significantly affect recurrence. Therefore, hasty treatment decisions are unnecessary for at least 6 months after diagnosis of early prostate cancer.

引用

页码：1083 / 1089

页数：7

共 25 条

[1] Delayed radical prostatectomy for intermediate-risk prostate cancer is associated with biochemical recurrence: Possible implications for active surveillance from the SEARCH database [J].