Parkinson's disease: oxidative stress and therapeutic approaches

被引：84
作者：
Surendran, Sankar [1 ]
Rajasankar, Srinivasagam [2 ]
机构：
[1] LSUHSC, Sch Med, New Orleans, LA 70112 USA
[2] Melmaruvathur Adhi Parasakthi Inst Med Sci, Dept Anat, Melmaruvathur, Tamil Nadu, India
来源：
NEUROLOGICAL SCIENCES | 2010年 / 31卷 / 05期
关键词：
Parkinson's disease; Antioxidant; Withania somnifera; Neurodegeneration; Canavan disease; MITOCHONDRIAL COMPLEX-I; DOPAMINE-DERIVED SALSOLINOL; N-ACETYLASPARTIC ACID; NITRIC-OXIDE SYNTHASE; SUBSTANTIA-NIGRA; ALPHA-SYNUCLEIN; COENZYME Q(10); UP-REGULATION; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE;
D O I：
10.1007/s10072-010-0245-1
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Parkinson's disease (PD) is a neurodegenerative disorder, caused by reduced levels of catecholamines and oxidative stress. Symptoms seen in the disease include tremor, rigidity, bradykinesia and postural disability. Oxidative stress plays a key role in neurodegeneration and motor abnormalities seen in PD. Altered levels of the protein caused by these changes lead to defective ubiquitin-proteasonne pathway. Neurodegeneration seen in PD and Canavan disease has a common mechanism. Recent studies suggest that herbal medicines can improve molecular changes and motor functions seen in PD.
引用
收藏
页码：531 / 540
页数：10
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