Parkinson's disease: oxidative stress and therapeutic approaches

被引：84

作者：

Surendran, Sankar ^{[1
]}

Rajasankar, Srinivasagam ^{[2
]}

机构：

[1] LSUHSC, Sch Med, New Orleans, LA 70112 USA

[2] Melmaruvathur Adhi Parasakthi Inst Med Sci, Dept Anat, Melmaruvathur, Tamil Nadu, India

来源：

NEUROLOGICAL SCIENCES | 2010年 / 31卷 / 05期

关键词：

Parkinson's disease; Antioxidant; Withania somnifera; Neurodegeneration; Canavan disease; MITOCHONDRIAL COMPLEX-I; DOPAMINE-DERIVED SALSOLINOL; N-ACETYLASPARTIC ACID; NITRIC-OXIDE SYNTHASE; SUBSTANTIA-NIGRA; ALPHA-SYNUCLEIN; COENZYME Q(10); UP-REGULATION; GLUTATHIONE-PEROXIDASE; SUPEROXIDE-DISMUTASE;

D O I：

10.1007/s10072-010-0245-1

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Parkinson's disease (PD) is a neurodegenerative disorder, caused by reduced levels of catecholamines and oxidative stress. Symptoms seen in the disease include tremor, rigidity, bradykinesia and postural disability. Oxidative stress plays a key role in neurodegeneration and motor abnormalities seen in PD. Altered levels of the protein caused by these changes lead to defective ubiquitin-proteasonne pathway. Neurodegeneration seen in PD and Canavan disease has a common mechanism. Recent studies suggest that herbal medicines can improve molecular changes and motor functions seen in PD.

引用

收藏

页码：531 / 540

页数：10

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