Coagulatory Defects in Type-1 and Type-2 Diabetes

被引：55

作者：

Sobczak, Amelie I. S. ^{[1
]}

Stewart, Alan J. ^{[1
]}

机构：

[1] Univ St Andrews, Sch Med, Med & Biol Sci Bldg, St Andrews KY16 9TF, Fife, Scotland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 24期

关键词：

atherosclerosis; endothelial dysfunction; magnesium; metal ions; microparticles; platelets; thrombosis; zinc; CHOLESTEROL EFFLUX CAPACITY; CORONARY-HEART-DISEASE; TISSUE FACTOR PATHWAY; ACTIVATABLE FIBRINOLYSIS INHIBITOR; ERYTHROCYTE-DERIVED MICROPARTICLES; DENSITY-LIPOPROTEIN FUNCTION; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; GLYCEMIC CONTROL; THROMBIN GENERATION;

D O I：

10.3390/ijms20246345

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.

引用

页数：27

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