Coagulatory Defects in Type-1 and Type-2 Diabetes

被引：57
作者：
Sobczak, Amelie I. S. [1 ]
Stewart, Alan J. [1 ]
机构：
[1] Univ St Andrews, Sch Med, Med & Biol Sci Bldg, St Andrews KY16 9TF, Fife, Scotland
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 24期
关键词：
atherosclerosis; endothelial dysfunction; magnesium; metal ions; microparticles; platelets; thrombosis; zinc; CHOLESTEROL EFFLUX CAPACITY; CORONARY-HEART-DISEASE; TISSUE FACTOR PATHWAY; ACTIVATABLE FIBRINOLYSIS INHIBITOR; ERYTHROCYTE-DERIVED MICROPARTICLES; DENSITY-LIPOPROTEIN FUNCTION; CARDIOVASCULAR-DISEASE; INSULIN-RESISTANCE; GLYCEMIC CONTROL; THROMBIN GENERATION;
D O I：
10.3390/ijms20246345
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Diabetes (both type-1 and type-2) affects millions of individuals worldwide. A major cause of death for individuals with diabetes is cardiovascular diseases, in part since both types of diabetes lead to physiological changes that affect haemostasis. Those changes include altered concentrations of coagulatory proteins, hyper-activation of platelets, changes in metal ion homeostasis, alterations in lipid metabolism (leading to lipotoxicity in the heart and atherosclerosis), the presence of pro-coagulatory microparticles and endothelial dysfunction. In this review, we explore the different mechanisms by which diabetes leads to an increased risk of developing coagulatory disorders and how this differs between type-1 and type-2 diabetes.
引用
收藏
页数：27
相关论文
共 212 条
  • [1] Effect of poor glycaemic control on plasma levels and activity of protein C, protein S, and antithrombin III in type 2 diabetes mellitus
    Addai-Mensah, Otchere
    Annani-Akollor, Max Efui
    Nsafoah, Frederick Obeng
    Fondjo, Linda Ahenkorah
    Owiredu, Eddie-Williams
    Danquah, Kwabena Owusu
    Duneeh, Richard Vikpebah
    Amponsah, Francis Agyei
    [J]. PLOS ONE, 2019, 14 (09):
  • [2] Increased Incorporation of Antiplasmin Into the Fibrin Network in Patients With Type 1 Diabetes
    Agren, Anna
    Jorneskog, Gun
    Elgue, Graciela
    Henriksson, Peter
    Wallen, Hakan
    Wiman, Bjorn
    [J]. DIABETES CARE, 2014, 37 (07) : 2007 - 2014
  • [3] Diabetes is associated with posttranslational modifications in plasminogen resulting in reduced plasmin generation and enzyme-specific activity
    Ajjan, Ramzi A.
    Gamlen, Toby
    Standeven, Kristina F.
    Mughal, Salihah
    Hess, Katharina
    Smith, Kerrie A.
    Dunn, Emma J.
    Anwar, M. Maqsud
    Rabbani, Naila
    Thornalley, Paul J.
    Philippou, Helen
    Grant, Peter J.
    [J]. BLOOD, 2013, 122 (01) : 134 - 142
  • [4] Iron status and its association with HbA1c levels in Dutch children with diabetes mellitus type 1
    Akkermans, Marjolijn D.
    Houdijk, E. C. A. Mieke
    Bakker, Boudewijn
    Clement-de Boers, Agnes
    van der Kaay, Danielle C. M.
    de Vries, Martine C.
    Woltering, M. Claire
    Mul, Dick
    van Goudoever, Johannes B.
    Brus, Frank
    [J]. EUROPEAN JOURNAL OF PEDIATRICS, 2018, 177 (04) : 603 - 610
  • [5] Magnesium and Human Health: Perspectives and Research Directions
    Al Alawi, Abdullah M.
    Majoni, Sandawana William
    Falhammar, Henrik
    [J]. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY, 2018, 2018
  • [6] Cardiolipotoxicity, Inflammation, and Arrhythmias: Role for Interleukin-6 Molecular Mechanisms
    Ali, Alessandra
    Boutjdir, Mohamed
    Aromolaran, Ademuyiwa S.
    [J]. FRONTIERS IN PHYSIOLOGY, 2019, 9
  • [7] Coagulation and fibrinolysis in diabetes
    Alzahrani, S. H.
    Ajjan, R. A.
    [J]. DIABETES & VASCULAR DISEASE RESEARCH, 2010, 7 (04) : 260 - 273
  • [8] Gender-Specific Alterations in Fibrin Structure Function in Type 2 Diabetes: Associations with Cardiometabolic and Vascular Markers
    Alzahrani, Saad H.
    Hess, Katharina
    Price, Jackie F.
    Strachan, Mark
    Baxter, Paul D.
    Cubbon, Richard
    Phoenix, Fladia
    Gamlen, T.
    Ariens, R. A. S.
    Grant, Peter J.
    Ajjan, Ramzi A.
    [J]. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2012, 97 (12) : E2282 - E2287
  • [9] Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes-2018
    不详
    [J]. DIABETES CARE, 2018, 41 : S86 - S104
  • [10] Lipoprotein hydrophobic core lipids are partially extruded to surface in smaller HDL: "Herniated" HDL, a common feature in diabetes
    Amigo, Nuria
    Mallol, Roger
    Heras, Mercedes
    Martinez-Hervas, Sergio
    Vaca, Francisco Blanco
    Escola-Gil, Joan Carles
    Plana, Nuria
    Yanes, Oscar
    Masana, Lluis
    Correig, Xavier
    [J]. SCIENTIFIC REPORTS, 2016, 6
12345678910