Oxytocin and microglia in the development of social behaviour

被引：13

作者：

Gonzalez, Alicia ^{[1
]}

Hammock, Elizabeth A. D. ^{[1
]}

机构：

[1] Florida State Univ, Dept Psychol, Program Neurosci, 1107 West Call St, Tallahassee, FL 32306 USA

来源：

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2022年 / 377卷 / 1858期

基金：

美国国家卫生研究院;

关键词：

oxytocin; microglia; development; social behaviour; sex differences; NF-KAPPA-B; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MESSENGER-RIBONUCLEIC-ACID; ESTROGEN-RECEPTOR BETA; NECROSIS-FACTOR-ALPHA; TNF-ALPHA; CRITICAL PERIOD; AMPA-RECEPTOR; NITRIC-OXIDE; SPINAL-CORD;

D O I：

10.1098/rstb.2021.0059

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oxytocin is a well-established regulator of social behaviour. Microglia, the resident immune cells of the central nervous system, regulate brain development and maintenance in health and disease. Oxytocin and microglia interact: microglia appear to regulate the oxytocin system and are, in turn, regulated by oxytocin, which appears to have anti-inflammatory effects. Both microglia and oxytocin are regulated in sex-specific ways. Oxytocin and microglia may work together to promote experience-dependent circuit refinement through multiple developmental-sensitive periods contributing to individual differences in social behaviour.This article is part of the theme issue 'Interplays between oxytocin and other neuromodulators in shaping complex social behaviours'.

引用

页数：16

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