Oxytocin and microglia in the development of social behaviour

被引：13
作者：
Gonzalez, Alicia [1 ]
Hammock, Elizabeth A. D. [1 ]
机构：
[1] Florida State Univ, Dept Psychol, Program Neurosci, 1107 West Call St, Tallahassee, FL 32306 USA
来源：
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES | 2022年 / 377卷 / 1858期
基金：
美国国家卫生研究院;
关键词：
oxytocin; microglia; development; social behaviour; sex differences; NF-KAPPA-B; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; MESSENGER-RIBONUCLEIC-ACID; ESTROGEN-RECEPTOR BETA; NECROSIS-FACTOR-ALPHA; TNF-ALPHA; CRITICAL PERIOD; AMPA-RECEPTOR; NITRIC-OXIDE; SPINAL-CORD;
D O I：
10.1098/rstb.2021.0059
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Oxytocin is a well-established regulator of social behaviour. Microglia, the resident immune cells of the central nervous system, regulate brain development and maintenance in health and disease. Oxytocin and microglia interact: microglia appear to regulate the oxytocin system and are, in turn, regulated by oxytocin, which appears to have anti-inflammatory effects. Both microglia and oxytocin are regulated in sex-specific ways. Oxytocin and microglia may work together to promote experience-dependent circuit refinement through multiple developmental-sensitive periods contributing to individual differences in social behaviour.This article is part of the theme issue 'Interplays between oxytocin and other neuromodulators in shaping complex social behaviours'.
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页数：16
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