Value and limitation of meta-analysis

被引：19

作者：

Verstraete, M ^{[1
]}

机构：

[1] Katholieke Univ Leuven, Ctr Mol & Vasc Biol, B-3000 Louvain, Belgium

来源：

PATHOPHYSIOLOGY OF HAEMOSTASIS AND THROMBOSIS | 2002年 / 32卷 / 5-6期

关键词：

D O I：

10.1159/000073581

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Meta-analysis is a valuable method of aggregating data sets of different trials which are inadequate or unconvincing on their own. There are strict rules on the retrieval and selection of data which are crucial in terms of the validity of a meta-analysis. Many so-called meta-analyses are flawed because of lack of a protocol or non adherence to it. Also underreporting of clinical trials is haunting the validity of meta-analysis. This hidden information is not a random process but is affecting mainly trials with negative results. To avoid this publication bias all clinical trials should enter an international online database. Copyright 2002 S. Karger AG. Basel.

引用

页码：278 / 281

页数：4

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