Two novel transgene integrations on the mouse Y chromosome

被引：0

作者：

Gardner, DP ^{[1
]}

Kappen, C ^{[1
]}

机构：

[1] Mayo Clin Arizona, Samuel C Johnson Med Res Ctr, Scottsdale, AZ 85259 USA

来源：

TRANSGENICS | 1998年 / 2卷 / 03期

关键词：

transgenic; Y-chromosome; mouse;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We here describe two independent transgenic lines of mice that transmit their corresponding transgene exclusively to male offspring. In all crosses with non-transgenic females, males are positive and females negative, These results strongly suggest that the transgenes have integrated on the mouse Y chromosome. The lack of positive females excludes the pseudoautosomal region as a candidate location for the transgenes, These transgene integrations may be useful as markers for detailed mapping of the mouse Y chromosome.

引用

页码：221 / 224

页数：4

共 10 条

[1]

[Anonymous], 1994, MANIPULATING MOUSE E

[2] MULTIPLEX GENE-REGULATION - A 2-TIERED APPROACH TO TRANSGENE REGULATION IN TRANSGENIC MICE [J].

BYRNE, GW ;

RUDDLE, FH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (14) :5473-5477

[3] Spatial and temporal regulation of a lacZ reporter transgene in a binary transgenic mouse system [J].

Gardner, DP ;

Byrne, GW ;

Ruddle, FH ;

Kappen, C .

TRANSGENIC RESEARCH, 1996, 5 (01) :37-48

[4]

NIELSEN LL, 1991, CANCER RES, V51, P3762

[5] MOSAIC EXPRESSION OF AN HPRT TRANSGENE INTEGRATED IN A REGION OF Y-HETEROCHROMATIN [J].

PRAVTCHEVA, DD ;

WISE, TL ;

ENSOR, NJ ;

RUDDLE, FH .

JOURNAL OF EXPERIMENTAL ZOOLOGY, 1994, 268 (06) :452-468

[6] RETROVIRUSES AND INSERTIONAL MUTAGENESIS IN MICE - PROVIRAL INTEGRATION AT THE MOV-34 LOCUS LEADS TO EARLY EMBRYONIC DEATH [J].

SORIANO, P ;

GRIDLEY, T ;

JAENISCH, R .

GENES & DEVELOPMENT, 1987, 1 (04) :366-375

[7] TRANSGENIC MOUSE CARRYING A FOREIGN GENE ON ITS Y-CHROMOSOME [J].

TOJO, H ;

FUKUMAKI, Y ;

OGITA, Z .

EXPERIMENTAL ANIMALS, 1988, 37 (03) :347-350

[8] TRANSGENIC MICE OVEREXPRESSING THE MOUSE HOMEOBOX-CONTAINING GENE HOX-1.4 EXHIBIT ABNORMAL GUT DEVELOPMENT [J].

WOLGEMUTH, DJ ;

BEHRINGER, RR ;

MOSTOLLER, MP ;

BRINSTER, RL ;

PALMITER, RD .

NATURE, 1989, 337 (6206) :464-467

[9]

YAMAMURA K, 1987, JPN J CANCER RES, V78, P681

[10] CONSERVED CYSTEINE TO SERINE MUTATION IN TYROSINASE IS RESPONSIBLE FOR THE CLASSICAL ALBINO MUTATION IN LABORATORY MICE [J].

YOKOYAMA, T ;

SILVERSIDES, DW ;

WAYMIRE, KG ;

KWON, BS ;

TAKEUCHI, T ;

OVERBEEK, PA .

NUCLEIC ACIDS RESEARCH, 1990, 18 (24) :7293-7298

← 1 →