Optimal planning and campaign scheduling of biopharmaceutical processes using a continuous-time formulation

被引:19
作者
Vieira, Miguel [1 ]
Pinto-Varela, Tania [1 ]
Moniz, Samuel [2 ]
Barbosa-Povoa, Ana P. [1 ]
Papageorgiou, Lazaros G. [3 ]
机构
[1] Univ Lisbon, Inst Super Tecn, CEG IST, Lisbon, Portugal
[2] INESC TEC, Oporto, Portugal
[3] UCL, Ctr Proc Syst Engn, London, England
关键词
Biopharmaceutical plants; Planning and campaign scheduling; Optimisation; Mixed integer linear programming; MULTIPURPOSE BATCH PLANTS; OPTIMIZATION; MANUFACTURE; ALGORITHM; UNCERTAINTY; STRATEGIES; FACILITIES;
D O I
10.1016/j.compchemeng.2016.04.009
中图分类号
TP39 [计算机的应用];
学科分类号
081203 ; 0835 ;
摘要
This work addresses the optimal planning and campaign scheduling of biopharmaceutical manufacturing processes, considering multiple operational characteristics, such as the campaign schedule of batch and/or continuous process steps, multiple intermediate deliveries, sequence dependent changeovers operations, product storage restricted to shelf-life limitations, and the track-control of the production/campaign lots due to regulatory policies. A new mixed integer linear programing (MILP) model, based on a Resource Task Network (RTN) continuous time single-grid formulation, is developed to comprise the integration of all these features. The performance of the model features is discussed with the resolution of a set of industrial problems with different data sets and process layouts, demonstrating the wide application of the proposed formulation. It is also performed a comparison with a related literature model, showing the advantages of the continuous-time approach and the generality of our model for the optimal production management of biopharmaceutical processes. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码:422 / 444
页数:23
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