Total synthesis and biological evaluation of tambjamine K and a library of unnatural analogs

被引：37

作者：

Aldrich, Leslie N. ^{[1
]}

Stoops, Sydney L. ^{[2
]}

Crews, Brenda C. ^{[3
]}

Marnett, Lawrence J. ^{[1
,2
,3
,4
]}

Lindsley, Craig W. ^{[1
,2
,4
]}

机构：

[1] Vanderbilt Univ, Dept Chem, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Pharmacol, Nashville, TN 37232 USA

[3] Vanderbilt Univ, Dept Biochem, Med Ctr, Nashville, TN 37232 USA

[4] Vanderbilt Inst Chem Biol, Nashville, TN 37232 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2010年 / 20卷 / 17期

关键词：

Tambjamine; Cancer; Total synthesis; NUDIBRANCH; MARINEOSINS; METABOLITES; ALKALOIDS; PIGMENT;

D O I：

10.1016/j.bmcl.2010.06.154

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Herein we disclose the first total synthesis of tambjamine K and a library of unnatural analogs. Unnatural analogs were shown to be more potent in viability, proliferation, and invasion assays than the natural product in multiple cancer cell lines, with minimal to no cytotoxicity on non-transformed cell lines. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5207 / 5211

页数：5

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