Fatty acid composition of human spermatozoa and seminal plasma levels of oxidative stress biomarkers in subfertile males

被引：76
作者：
Khosrowbeygi, Ali
Zarghami, Nosratollah [1 ]
机构：
[1] Tabriz Univ Med Sci, Drug Appl Res Ctr, Dept Clin Biochem & Radiopharm, Tabriz, Iran
[2] Lorestan Univ Med Sci, Sch Med, Dept Biochem, Khorramabad, Iran
来源：
PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS | 2007年 / 77卷 / 02期
关键词：
D O I：
10.1016/j.plefa.2007.08.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Introduction: The lipid composition of the sperm membrane has a significant effect on the functional characteristics of spermatozoa. Patients and methods: In the present study, fatty acid composition of spermatozoa and seminal plasma levels of free 15-F-2t-Isoprostane and catalase were assayed in men with normozoospermia, asthenozoospermia, asthenoteratozoospermia, and oligoasthenoteratozoospermia. Results: In spermatozoa from asthenozoospermic men only oleic acid levels showed a significant difference from normozoospermic men. In spermatozoa from asthenoteratozoospermic and oligoasthenoteratozoospermic samples all of the tested fatty acids were significantly higher than those from normozoospermic samples. Seminal plasma levels of catalase were significantly lower in all patients while levels of free 15-F2t-Isoprostane were significantly higher in all patients compared with normozoospermic men. Discussion: Spermatozoa from pathological samples may have higher levels of polyunsaturated fatty acids, especially docosahexaenoic acid (DHA), than spermatozoa from normozoospermic men. Therefore, damage induced by lipid peroxidation would be higher in spermatozoa from pathological samples than those from normozoospermic men. (C) 2007 Elsevier Ltd. All rights reserved.
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页码：117 / 121
页数：5
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