Hematopoietic stem and progenitor cells: Clinical and preclinical regeneration of the hematolymphoid system

被引：249

作者：

Shizuru, JA ^{[1
]}

Negrin, RS

Weissman, IL

机构：

[1] Stanford Univ, Med Ctr, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA

[2] Stanford Univ, Med Ctr, Dept Pathol, Stanford, CA 94305 USA

来源：

ANNUAL REVIEW OF MEDICINE | 2005年 / 56卷

关键词：

bone marrow; embryonic stem cell; transplantation; cancer; autoimmune;

D O I：

10.1146/annurev.med.54.101601.152334

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

A vast literature exists on the biology of blood formation and regeneration under experimental and clinical conditions. The field of hematopoiesis was recently advanced by the capacity to purify to homogeneity primitive hematopoietic stem and progenitor cells. Isolation of cells at defined maturational stages has enhanced the understanding of the fundamental nature of stem cells, including how cell fate decisions are made, and this understanding is relevant to the development of other normal as well as malignant tissues. This review updates the basic biology of hematopoietic stem cells (HSC) and progenitors, the evolving use of purified HSC as grafts for clinical hematopoietic cell transplantation (HCT) including immune tolerance induction, and the application of HSC biology to other stem cell fields.

引用

页码：509 / 538

页数：30

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