Synthesis and in vitro cytotoxic evaluation of N-alkylbromo and N-alkylphthalimido-isatins

被引：46
|
作者：
Singh, Pardeep [1 ]
Kaur, Sharanjeet [2 ]
Kumar, Vipan [1 ]
Bedi, P. M. S. [2 ]
Mahajan, M. P. [1 ]
Sehar, Irum [3 ]
Pal, Harish Chandra [3 ]
Saxena, Ajit Kumar [3 ]
机构：
[1] Guru Nanak Dev Univ, Dept Chem, Amritsar 143005, Punjab, India
[2] Guru Nanak Dev Univ, Dept Pharmaceut Sci, Amritsar 143005, Punjab, India
[3] Indian Inst Integrat Med, Canc Pharmacol Div, Jammu 180001, J&K, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 10期
关键词：
N-Alkylbromo-isatins; N-Alkylphthalimido-isatins; Cytotoxic evaluation; THP-1 (Leukemia); HeLa (Cervix); AGENTS; DERIVATIVES; QUINAZOLINES; INHIBITORS; OXINDOLES; ANALOGS; CELLS;
D O I：
10.1016/j.bmcl.2011.03.043
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The manuscript pertains to the synthesis and in vitro cytotoxic evaluation of a series of N-alkylbromo and N-alkylphthalimido-isatins against four different human cancer cell lines namely Colon: HCT-15; Liver: Hep-2; Lung: A-549 and Leukemia: THP-1 at 10 and 100 mu M concentrations. The active compounds based on preliminary studies were evaluated for their IC(50) value against six cell lines viz. Colo-205, HCT-15 (Colon), THP-1 (Leukemia), A-549 (Lung), PC-3 (Prostate) and HeLa (Cervix). The active analogue IS-4 exhibited IC(50) values of 4.57, 10.90, 11.75, 12.40 and 54.20 mu M against HeLa, PC-3, HCT-15, THP-1 and Colo-205, respectively. (C) 2011 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3017 / 3020
页数：4
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