Remdesivir-Associated Sinus Arrest in COVID-19: A Potential Indication for Close Cardiac Monitoring

被引：1
作者：
Gregory, Grant E. [1 ]
Gregory, Hannah M. [2 ]
Liaqat, Hamza [3 ]
Ghaly, Mina M. [4 ]
Johnson-Pich, Kristy D. [4 ]
机构：
[1] Alabama Coll Osteopath Med, Sch Med, Dothan, AL 36303 USA
[2] Alabama Coll Osteopath Med, Anesthesiol & Crit Care, Dothan, AL USA
[3] Wah Med Coll, Internal Med, Wah Cantonment, Pakistan
[4] Southeast Hlth Med Ctr, Internal Med, Dothan, AL USA
来源：
CUREUS JOURNAL OF MEDICAL SCIENCE | 2022年 / 14卷 / 02期
关键词：
antiviral therapy; drug-induced bradycardia; sinus arrest; remdesivir; covid; 19;
D O I：
10.7759/cureus.22328
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Remdesivir is an antiviral, nucleoside analog used extensively during the coronavirus-disease 2019 (COVID19) pandemic with proven efficacy against COVID-19-induced acute respiratory distress syndrome (ARDS). Our case report details the clinical course of a 50-year-old, COVID-19-positive patient who developed sinus arrest after being treated with remdesivir. Within 24 hours of discontinuing remdesivir therapy, the patient's sinus arrest resolved to a normal sinus rhythm. The findings from our case report add to a growing body of evidence on the cardiotoxic profile of remdesivir. Remdesivir's ability to cause bradyarrhythmias, and specifically sinus arrest, should be acknowledged when considering the use of this drug in at-risk patients.
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