Usefulness of Aquaporin 1 as a Prognostic Marker in a Prospective Cohort of Malignant Mesotheliomas

被引:8
作者
Driml, Jack [1 ]
Pulford, Emily [1 ]
Moffat, David [2 ]
Karapetis, Christos [3 ]
Kao, Steven [4 ]
Griggs, Kim [1 ]
Henderson, Douglas Warrington [2 ]
Klebe, Sonja [1 ,2 ]
机构
[1] Flinders Univ South Australia, Dept Anat Pathol, Bedford Pk, SA 5042, Australia
[2] SA Pathol, Flinders Med Ctr, Dept Surg Pathol, Bedford Pk, SA 5042, Australia
[3] Flinders Med Ctr, Med Oncol, Bedford Pk, SA 5042, Australia
[4] Concord Repatriat Gen Hosp, Asbestos Dis Res Inst, Bernie Banton Ctr, Sydney, NSW 2139, Australia
关键词
malignant mesothelioma; pleura; peritoneum; Aquaporin; 1; asbestos; prognosis; WATER CHANNEL PROTEIN; EXPRESSION; VEGF; ANGIOGENESIS; CANCER; AQP1; SURVIVAL;
D O I
10.3390/ijms17071041
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
(1) Background: Malignant mesothelioma (MM) is an aggressive tumour of the serosal membranes, associated with exposure to asbestos. Survival is generally poor, but prognostication for individual patients is difficult. We recently described Aquaporin 1 (AQP1) as independent prognostic factor in two separate retrospective cohorts of MM patients. Here we assess the usefulness of AQP1 prospectively, and determine the inter-observer agreement in assessing AQP1 scores; (2) Methods: A total of 104 consecutive cases of MM were included. Sufficient tissue for immunohistochemistry was available for 100 cases, and these cases were labelled for AQP1. Labelling was assessed by two pathologists. Complete clinical information and follow up was available for 91 cases; (3) Results: Labelling of 50% of tumour cells for AQP indicated improved prognosis in a univariate model (median survival 13 versus 8 months, p = 0.008), but the significance was decreased in a multivariate analysis. Scoring for AQP1 was robust, with an inter-observer kappa value of 0.722, indicating substantial agreement between observers; (4) Conclusion: AQP1 is a useful prognostic marker that can be easily incorporated in existing diagnostic immunohistochemical panels and which can be reliably interpreted by different pathologists.
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页数:7
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