Obesity and Cancer Progression: Is There a Role of Fatty Acid Metabolism?

被引：80
作者：
Balaban, Seher [1 ,2 ,3 ]
Lee, Lisa S. [1 ,2 ,3 ]
Schreuder, Mark [1 ,2 ]
Hoy, Andrew J. [1 ,2 ,3 ,4 ]
机构：
[1] Univ Sydney, Sch Med Sci, Discipline Physiol, Sydney, NSW 2006, Australia
[2] Univ Sydney, Bosch Inst, Sydney, NSW 2006, Australia
[3] Univ Sydney, Charles Perkins Ctr, Sydney, NSW 2006, Australia
[4] Univ Sydney, Boden Inst Obes Nutr Exercise & Eating Disorders, Sydney, NSW 2006, Australia
来源：
BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷
关键词：
HORMONE-SENSITIVE LIPASE; ADIPOSE TRIGLYCERIDE LIPASE; ACYL-COA SYNTHETASE; CARNITINE PALMITOYLTRANSFERASE-I; MECHANISMS LINKING OBESITY; BINDING PROTEINS FABPS; COENZYME-A CARBOXYLASE; BETA LPAAT-BETA; SKELETAL-MUSCLE; LIPOPROTEIN-LIPASE;
D O I：
10.1155/2015/274585
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Currently, there is renewed interest in elucidating the metabolic characteristics of cancer and how these characteristics may be exploited as therapeutic targets. Much attention has centered on glucose, glutamine and de novo lipogenesis, yet the metabolism of fatty acids that arise from extracellular, as well as intracellular, stores as triacylglycerol has received much less attention. This review focuses on the key pathways of fatty acid metabolism, including uptake, esterification, lipolysis, and mitochondrial oxidation, and how the regulators of these pathways are altered in cancer. Additionally, we discuss the potential link that fatty acid metabolism may serve between obesity and changes in cancer progression.
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页数：17
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