Rapid Magnetic Nanobiosensor for the detection of Serratia marcescen

被引：15

作者：

Aljabali, Alaa A. A. ^{[1
]}

Hussein, Emad ^{[2
,3
]}

Aljumaili, Omar ^{[2
]}

Al Zoubi, Mazhar ^{[2
]}

Altrad, Bahaa ^{[2
]}

Albatayneh, Khaled ^{[2
]}

Abd Al-razaq, Mutaz A. ^{[2
]}

机构：

[1] Yarmouk Univ, Fac Pharm, Irbid, Jordan

[2] Yarmouk Univ, Fac Sci, Dept Biol Sci, Irbid, Jordan

[3] A Sharqiyah Univ, Coll Appl Sci, Dept Food Sci & Human Nutr, Ibra, Oman

来源：

2ND INTERNATIONAL CONFERENCE ON ADVANCED MATERIALS (ICAM-2017) | 2018年 / 305卷

关键词：

Bacterial detection; Iron Oxide Nanoparticles; Antibody Detection; Sensor; IRON-OXIDE NANOPARTICLES; FOODBORNE PATHOGEN; QUANTUM DOTS; INFECTIONS; MICROSCOPY; IMPEDANCE; RECEPTOR; TUMORS; CELLS; DRUG;

D O I：

10.1088/1757-899X/305/1/012005

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

The development of rapid, sensitive, accurate and reliable bacterial detection methods are of keen interest to ensure food safety and hospital security. Therefore, the development of a fast, specific, low-cost and trusted methods is in high demand Magnetic nanoparticles with their unique material properties have been utilized as a tool for pathogen detection. Here, we present a novel iron oxide nanoparticles labeled with specific targeting antibodies to improve specificity and extend the use of nanoparticles as nanosensors. The results indicated that antibody labeled iron oxide platform that binds specifically to Serriata marcescenst in a straightforward method is very specific and sensitive. The system is capable of rapid and specific detection of various clinically relevant bacterial species, with sensitivity down to single bacteria. The generic platform could be used to identify pathogens for a variety of applications rapidly.

引用

页数：20

共 51 条

[1] Biofunctional quantum dots as fluorescence probe for cell-specific targeting [J].