Calcium Carbonate/Carboxymethyl Chitosan Hybrid Microspheres and Nanospheres for Drug Delivery

被引：163

作者：

Wang, Jun ^{[1
]}

Chen, Ji-Si ^{[1
]}

Zong, Jing-Yi ^{[1
]}

Zhao, Dong ^{[1
]}

Li, Feng ^{[1
]}

Zhuo, Ren-Xi ^{[1
]}

Cheng, Si-Xue ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Minist Educ, Key Lab Biomed Polymers, Wuhan 430072, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY C | 2010年 / 114卷 / 44期

基金：

中国国家自然科学基金;

关键词：

CARBOXYMETHYL-CHITOSAN; NANOPARTICLES; CARBONATE;

D O I：

10.1021/jp105906p

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Calcium carbonate/carboxymethyl chitosan (CaCO3/CMC) hybrid microspheres and nanospheres were prepared by the precipitation of calcium carbonate in an aqueous solution containing CMC. Through adjusting the preparation conditions, the size of CaCO3/CMC hybrid particles could be easily controlled at micro- to nanometer ranges with relatively narrow size distributions. The obtained microspheres and nanospheres were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, thermogravimetric analysis, and differential scanning calorimetry. The size and size distribution were measured by a particle size analyzer. Doxorubicin hydrochloride (DOX center dot HCl), a water-soluble anticancer drug, was loaded in the hybrid microspheres and nanospheres with a high encapsulation efficiency. The in vitro drug release showed that the release of DOX center dot HCl from the microspheres and nanospheres could be effectively sustained.

引用

页码：18940 / 18945

页数：6

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