Osteopontin-derived peptide SVVYGLR induces angiogenesis in vivo

被引：55

作者：

Hamada, Y ^{[1
]}

Yuki, K

Okazaki, M

Fujitani, W

Matsumoto, T

Hashida, MK

Harutsugu, K

Nokihara, K

Daito, M

Matsuura, N

Takahashi, J

机构：

[1] Osaka Univ, Grad Sch Dent, Dept Biomat Sci, Osaka 5650871, Japan

[2] Osaka Univ, Grad Sch Med & Hlth Sci, Dept Mol Pathol, Osaka 5650871, Japan

[3] Hiroshima Univ, Grad Sch Biomed Sci, Dept Biomat Sci, Hiroshima 7348553, Japan

[4] Osaka Univ, Grad Sch Engn, Dept Mat Sci & Engn, Osaka 5650871, Japan

[5] Osaka Dent Univ, Dept Pediat Dent, Osaka 5731121, Japan

[6] Hipep Labs Inc, Kyoto 6028158, Japan

来源：

DENTAL MATERIALS JOURNAL | 2004年 / 23卷 / 04期

关键词：

angiogenesis; endothelial cells; SVVYGLR;

D O I：

10.4012/dmj.23.650

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

Our previous study reported that an osteopontin-derived peptide SVVYGLR activates the adhesion, migration and tube formation abilities of endothelial cells in vitro. The present study investigated angiogenesis due to synthetic SVVYGLR and mutant peptides in vivo. Mutant peptides (n = 7) were synthesized by substituting alanine (A) for one of the 7 amino acids comprising SVVYGLR. In dorsal air sac assay, mouse dorsal skin 5 days after implantation of a chamber filled with SVVYGLR had approximately the same number of newly formed blood vessels to that filled with vascular endothelial growth factor (VEGF). The ability of angiogenesis due to SVVAGLR was significantly lower than that due to other 6 mutant peptides and SVVYGLR. This indicates that tyrosine (Y) plays an important role in angiogenesis due to SVVYGLR.

引用

页码：650 / 655

页数：6

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