Alkaloids from Marine Invertebrates as Important Leads for Anticancer Drugs Discovery and Development

被引：52

作者：

Imperatore, Concetta ^{[1
]}

Aiello, Anna ^{[1
]}

D'Aniello, Filomena ^{[1
]}

Senese, Maria ^{[1
]}

Menna, Marialuisa ^{[1
]}

机构：

[1] Univ Naples Federico II, Dept Pharm, NeaNat Grp, I-80131 Naples, Italy

来源：

MOLECULES | 2014年 / 19卷 / 12期

关键词：

alkaloids; marine invertebrates; anticancer; natural products; drug discovery; CYTOTOXIC PYRIDOACRIDINE ALKALOIDS; TUNICATE CYSTODYTES-DELLECHIAJEI; SPONGE KIRKPATRICKIA-VARIALOSA; TETRACYCLIC AROMATIC ALKALOIDS; NUCLEOTIDE-EXCISION-REPAIR; FORMAL TOTAL-SYNTHESIS; SOFT-TISSUE SARCOMAS; LAMELLARIN-D; NATURAL-PRODUCT; VARIOLIN-B;

D O I：

10.3390/molecules191220391

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery.

引用

页码：20391 / 20423

页数：33

共 139 条

[1]

Alvarez M., 2002, Patent No. [WO2002012240 A1, 2002012240]

[2] METABOLITIES OF THE MARINE PROSOBRANCH MOLLUSK LAMELLARIA SP [J].