STUDIES OF THE DEGRADATION MECHANISM OF PYRROLO[3,4-C] PYRIDINE-1,3(2H)-DIONE DERIVATIVES WITH ANALGESIC ACTIVITY: ISOLATION AND IDENTIFICATION OF PRODUCTS AND SUMMARY

Within the framework of the studies concerning the decomposition of N-substituted derivatives of 4-alkoxy-6-methyl-1H-pyrrolo[3,4-Opyridine-1,3(2H)-dione, the isolation of the alkaline hydrolysis product was performed (pH 10.5, room temperature). Subsequently, based on NMR spectra and two-dimensional spectra, the chemical structure of the isolated compounds was established. The interpretation of COSY. HSQC and HMBC spectra proved that the C(1)-N(2) bond of the pyrrolopyridinedione ring undergoes cleavage under the influence of OH ions and generates a product which is an isonicotinic acid derivative. Owing to the analysis of previous studies, including results presented in this paper, the decomposition mechanism of the compounds studied could be determined.