End-organ damage in hyperlipidemias

被引：0

作者：

Faust, M ^{[1
]}

Krone, W ^{[1
]}

机构：

[1] Univ Cologne, Klin & Poliklin Innere Med 2, D-50924 Cologne, Germany

来源：

INTERNIST | 2003年 / 44卷 / 07期

关键词：

hypercholesterolemia; hypertriglyceridemia; atherosclerosis; coronary heart disease; stroke;

D O I：

10.1007/s00108-003-0954-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epidemiological and experimental data have clearly demonstrated a strong association between elevated LDL-cholesterol levels and coronary heart disease. In concordance lipid-lowering trials with statins have shown a significant reduction of cardiovascular events. Although stroke is mainly caused by atherosclerotic vascular events, epidemiolgical data have so far failed to show a significant relationship between elevated lipid levels and stroke incidence. However, recent lipid intervention trials with statins have clearly demonstrated a significant reduction in stroke incidence. Moreover, elevated cholesterol levels are thought to contribute to progression of chronic renal insufficiency. In addition, cholesterol crystal emboli are a rare but frequently serious complication of vascular catheter interventions. Significant hypertriglyceridemia carries a significant risk of acute pancreatitis and is thought to contribute to the development of fatty liver disease.

引用

页码：831 / +

页数：7

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