End-organ damage in hyperlipidemias

被引：0
|
作者：
Faust, M [1 ]
Krone, W [1 ]
机构：
[1] Univ Cologne, Klin & Poliklin Innere Med 2, D-50924 Cologne, Germany
来源：
INTERNIST | 2003年 / 44卷 / 07期
关键词：
hypercholesterolemia; hypertriglyceridemia; atherosclerosis; coronary heart disease; stroke;
D O I：
10.1007/s00108-003-0954-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Epidemiological and experimental data have clearly demonstrated a strong association between elevated LDL-cholesterol levels and coronary heart disease. In concordance lipid-lowering trials with statins have shown a significant reduction of cardiovascular events. Although stroke is mainly caused by atherosclerotic vascular events, epidemiolgical data have so far failed to show a significant relationship between elevated lipid levels and stroke incidence. However, recent lipid intervention trials with statins have clearly demonstrated a significant reduction in stroke incidence. Moreover, elevated cholesterol levels are thought to contribute to progression of chronic renal insufficiency. In addition, cholesterol crystal emboli are a rare but frequently serious complication of vascular catheter interventions. Significant hypertriglyceridemia carries a significant risk of acute pancreatitis and is thought to contribute to the development of fatty liver disease.
引用
收藏
页码：831 / +
页数：7
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