End-organ damage in hyperlipidemias

被引：0
|
作者：
Faust, M [1 ]
Krone, W [1 ]
机构：
[1] Univ Cologne, Klin & Poliklin Innere Med 2, D-50924 Cologne, Germany
来源：
INTERNIST | 2003年 / 44卷 / 07期
关键词：
hypercholesterolemia; hypertriglyceridemia; atherosclerosis; coronary heart disease; stroke;
D O I：
10.1007/s00108-003-0954-0
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Epidemiological and experimental data have clearly demonstrated a strong association between elevated LDL-cholesterol levels and coronary heart disease. In concordance lipid-lowering trials with statins have shown a significant reduction of cardiovascular events. Although stroke is mainly caused by atherosclerotic vascular events, epidemiolgical data have so far failed to show a significant relationship between elevated lipid levels and stroke incidence. However, recent lipid intervention trials with statins have clearly demonstrated a significant reduction in stroke incidence. Moreover, elevated cholesterol levels are thought to contribute to progression of chronic renal insufficiency. In addition, cholesterol crystal emboli are a rare but frequently serious complication of vascular catheter interventions. Significant hypertriglyceridemia carries a significant risk of acute pancreatitis and is thought to contribute to the development of fatty liver disease.
引用
收藏
页码：831 / +
页数：7
相关论文
共 50 条
  • [1] Aldosterone and end-organ damage
    Brown, NJ
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 2005, 14 (03): : 235 - 241
  • [2] Aldosterone and end-organ damage
    Marney, Annis M.
    Brown, Nancy J.
    CLINICAL SCIENCE, 2007, 113 (5-6) : 267 - 278
  • [3] Hypertension, nitric oxide and end-organ damage
    Ishani, A
    Raij, L
    CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION, 1999, 8 (02): : 237 - 241
  • [4] High blood pressure and end-organ damage
    Cutler, JA
    JOURNAL OF HYPERTENSION, 1996, 14 : S3 - S6
  • [5] Isolated office hypertension and end-organ damage
    Ferrara, LA
    Guida, L
    Pasanisi, F
    Celentano, A
    Palmieri, V
    Iannuzzi, R
    Gaeta, I
    Leccia, G
    Crivaro, M
    JOURNAL OF HYPERTENSION, 1997, 15 (09) : 979 - 985
  • [6] Inflammation, Immunity, and Hypertensive End-Organ Damage
    McMaster, William G.
    Kirabo, Annet
    Madhur, Meena S.
    Harrison, David G.
    CIRCULATION RESEARCH, 2015, 116 (06) : 1022 - 1033
  • [7] Central Blood Pressure and End-organ Damage
    Kohara, Katsuhiko
    CURRENT HYPERTENSION REVIEWS, 2012, 8 (02) : 100 - 107
  • [8] PATHOPHYSIOLOGY AND END-ORGAN DAMAGE IN ELDERLY HYPERTENSIVES
    SHIMADA, K
    MIYASHITA, H
    KAWAMOTO, A
    MATSUBAYASHI, K
    NISHINAGA, M
    KIMURA, S
    OZAWA, T
    JOURNAL OF HYPERTENSION, 1994, 12 : S7 - S12
  • [9] GENETICS OF ALCOHOLISM AND RELATED END-ORGAN DAMAGE
    DEVOR, EJ
    REICH, T
    CLONINGER, CR
    SEMINARS IN LIVER DISEASE, 1988, 8 (01) : 1 - 11
  • [10] Brain injury as end-organ damage in hypertension
    Scuteri, Angelo
    LANCET NEUROLOGY, 2012, 11 (12): : 1015 - 1017
12345