Structural studies on the interactions between metal ions and biological macromolecules

被引：0
|
作者：
Orioli, P [1 ]
机构：
[1] Univ Florence, Dept Chem, I-50121 Florence, Italy
来源：
CROATICA CHEMICA ACTA | 1998年 / 71卷 / 03期
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The essential role of metal ions in biology is stressed by structural investigations on two metalloenzymes: human carbonic anhydrase (CA) and Cu, Zn superoxide dismutase (SOD) The X-ray structure of CA complex with histamine affords a satisfactory explanation of the mechanism of activation of CA. The high resolution (1.02 Angstrom crystal structure of a mutant monomeric Cu, Zn superoxide dismutase gives relevant information on the mechanism of the catalytic activity of the native dimeric enzyme and on the reduced activity of the monomer.
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页码：659 / 672
页数：14
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