The role of granulocyte colony-stimulating factor in breast cancer development: A review

被引：42
作者：
Liu, Li [1 ,2 ,3 ]
Liu, Yangyang [4 ]
Yan, Xiaohua [1 ]
Zhou, Chong [1 ]
Xiong, Xiangyang [1 ]
机构：
[1] Nanchang Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, 461 Bayi Ave, Nanchang 330006, Jiangxi, Peoples R China
[2] China Three Gorges Univ, Cent Lab, Coll Clin Med Sci 1, Yichang 443003, Hubei, Peoples R China
[3] Yichang Cent Peoples Hosp, Yichang 443003, Hubei, Peoples R China
[4] Nanchang Univ, Dept Anesthesiol, Clin Med Coll 1, Sch Med, Nanchang 330006, Jiangxi, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2020年 / 21卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Granulocyte-colony-stimulating factor; granulocyte-colony-stimulating factor receptor; breast cancer; tumorigenesis; tumor microenvironment; NECROSIS-FACTOR-ALPHA; FACTOR G-CSF; TUMOR-ASSOCIATED MACROPHAGES; FACTOR-RECEPTOR; GM-CSF; SUPPRESSOR-CELLS; DESTABILIZING ELEMENT; GLOBULAR ADIPONECTIN; TRANSCRIPTION FACTOR; REGULATORY ELEMENTS;
D O I：
10.3892/mmr.2020.11017
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Granulocyte-colony-stimulating factor (G-CSF) is a member of the hematopoietic growth factor family that primarily affects the neutrophil lineage. G-CSF serves as a powerful mobilizer of peripheral blood stem cells and recombinant human G-CSF (rhG-CSF) has been used to treat granulocytopenia and neutropenia after chemotherapy for cancer patients. However, recent studies have found that G-CSF plays an important role in cancer progression. G-CSF expression is increased in different types of cancer cells, such as lung cancer, gastric cancer, colorectal cancer, invasive bladder carcinoma, glioma and breast cancer. However, it is unclear whether treatment with G-CSF has an adverse effect. The current review provides an overview of G-CSF in malignant breast cancer development and the data presented in this review are expected to provide new ideas for cancer therapy.
引用
收藏
页码：2019 / 2029
页数：11
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