SKY reveals a high frequency of unbalanced translocations involving chromosome 6 in t(12;21)-positive acute lymphoblastic leukemia

被引：10

作者：

Betts, David R. ^{[1
]}

Stanchescu, Rachell ^{[2
,3
]}

Niggli, Felix K. ^{[1
]}

Cohen, Ninette ^{[2
,3
]}

Rechavi, Gideon ^{[2
,3
]}

Amariglio, Ninette ^{[2
,3
]}

Trakhtenbrot, Luba ^{[2
,3
]}

机构：

[1] Univ Childrens Hosp, Dept Oncol, CH-8032 Zurich, Switzerland

[2] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

[3] Chaim Sheba Med Ctr, Canc Res Ctr, IL-52621 Tel Hashomer, Israel

来源：

LEUKEMIA RESEARCH | 2008年 / 32卷 / 01期

关键词：

acute lyruphoblastic leukeinia; karyotyping; SKY; child;

D O I：

10.1016/j.leukres.2007.03.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The G-band cryptic t(12;21)(p13;q22) is the most common chromosomal rearrangement in childhood acute lymphoblastic leukemia (ALL). To investigate the nature of additional chromosomal events in this group of patients spectral karyotyping (SKY) following G-banding analysis was performed in 14 cases. From these cases six showed structural aberrations of chromosome 6, including both simple deletions and unbalanced translocations, and involved both cl (n = 4) and p (n = 3) arms. The results show that rearrangements of 6p are also non-random events t(12;21)-positive ALL. This Study illustrates the value of a combined SKY and G-banding approach in identifying novel karyotypic events in childhood ALL. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：39 / 43

页数：5

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