Systematic approach to understanding the pathogenesis of systemic sclerosis

被引：21

作者：

Zuo, Xiaoxia ^{[1
]}

Zhang, Lihua ^{[1
]}

Luo, Hui ^{[1
]}

Li, Yisha ^{[1
]}

Zhu, Honglin ^{[1
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Dept Rheumatol, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

来源：

CLINICAL GENETICS | 2017年 / 92卷 / 04期

基金：

国家高技术研究发展计划(863计划); 中国国家自然科学基金;

关键词：

combination; multi-omics; pathogenesis; systemic sclerosis; GENOME-WIDE ASSOCIATION; PULMONARY ARTERIAL-HYPERTENSION; GENE-EXPRESSION PATTERNS; PERIPHERAL-BLOOD CELLS; DERMAL FIBROBLASTS; LUPUS-ERYTHEMATOSUS; SUSCEPTIBILITY LOCI; SCLERODERMA FIBROBLASTS; RHEUMATOID-ARTHRITIS; PROTEOMIC ANALYSIS;

D O I：

10.1111/cge.12946

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Systemic sclerosis (SSc) is a complex heterogeneous autoimmune disease. Progressive organ fibrosis is a major contributor to SSc mortality. Despite extensive efforts, the underlying mechanism of SSc remains unclear. Efforts to understand the pathogenesis of SSc have included genomics, epigenetics, transcriptomic, proteomic and metabolomic studies in the last decade. This review focuses on recent studies in SSc research based on multi-omics. The combination of these technologies can help us understand the pathogenesis of SSc. This review aims to provide important information for disease identification, therapeutic targets and potential biomarkers.

引用

页码：365 / 371

页数：7

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