Systematic approach to understanding the pathogenesis of systemic sclerosis

被引:21
作者
Zuo, Xiaoxia [1 ]
Zhang, Lihua [1 ]
Luo, Hui [1 ]
Li, Yisha [1 ]
Zhu, Honglin [1 ]
机构
[1] Cent S Univ, Xiangya Hosp, Dept Rheumatol, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China
基金
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词
combination; multi-omics; pathogenesis; systemic sclerosis; GENOME-WIDE ASSOCIATION; PULMONARY ARTERIAL-HYPERTENSION; GENE-EXPRESSION PATTERNS; PERIPHERAL-BLOOD CELLS; DERMAL FIBROBLASTS; LUPUS-ERYTHEMATOSUS; SUSCEPTIBILITY LOCI; SCLERODERMA FIBROBLASTS; RHEUMATOID-ARTHRITIS; PROTEOMIC ANALYSIS;
D O I
10.1111/cge.12946
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Systemic sclerosis (SSc) is a complex heterogeneous autoimmune disease. Progressive organ fibrosis is a major contributor to SSc mortality. Despite extensive efforts, the underlying mechanism of SSc remains unclear. Efforts to understand the pathogenesis of SSc have included genomics, epigenetics, transcriptomic, proteomic and metabolomic studies in the last decade. This review focuses on recent studies in SSc research based on multi-omics. The combination of these technologies can help us understand the pathogenesis of SSc. This review aims to provide important information for disease identification, therapeutic targets and potential biomarkers.
引用
收藏
页码:365 / 371
页数:7
相关论文
共 75 条
[51]   Limited Systemic Sclerosis Patients with Pulmonary Arterial Hypertension Show Biomarkers of Inflammation and Vascular Injury [J].
Pendergrass, Sarah A. ;
Hayes, Everett ;
Farina, Giuseppina ;
Lemaire, Raphael ;
Farber, Harrison W. ;
Whitfield, Michael L. ;
Lafyatis, Robert .
PLOS ONE, 2010, 5 (08)
[52]   Genome-wide association study of systemic sclerosis identifies CD247 as a new susceptibility locus [J].
Radstake, Timothy R. D. J. ;
Gorlova, Olga ;
Rueda, Blanca ;
Martin, Jose-Ezequiel ;
Alizadeh, Behrooz Z. ;
Palomino-Morales, Rogelio ;
Coenen, Marieke J. ;
Vonk, Madelon C. ;
Voskuyl, Alexandre E. ;
Schuerwegh, Annemie J. ;
Broen, Jasper C. ;
van Riel, Piet L. C. M. ;
van't Slot, Ruben ;
Italiaander, Annet ;
Ophoff, Roel A. ;
Riemekasten, Gabriela ;
Hunzelmann, Nico ;
Simeon, Carmen P. ;
Ortego-Centeno, Norberto ;
Gonzalez-Gay, Miguel A. ;
Gonzalez-Escribano, Maria F. ;
Airo, Paolo ;
van Laar, Jaap ;
Herrick, Ariane ;
Worthington, Jane ;
Hesselstrand, Roger ;
Smith, Vanessa ;
de Keyser, Filip ;
Houssiau, Fredric ;
Chee, Meng May ;
Madhok, Rajan ;
Shiels, Paul ;
Westhovens, Rene ;
Kreuter, Alexander ;
Kiener, Hans ;
de Baere, Elfride ;
Witte, Torsten ;
Padykov, Leonid ;
Klareskog, Lars ;
Beretta, Lorenzo ;
Scorza, Rafaella ;
Lie, Benedicte A. ;
Hoffmann-Vold, Anna-Maria ;
Carreira, Patricia ;
Varga, John ;
Hinchcliff, Monique ;
Gregersen, Peter K. ;
Lee, Annette T. ;
Ying, Jun ;
Han, Younghun .
NATURE GENETICS, 2010, 42 (05) :426-U71
[53]   A Longitudinal Biomarker for the Extent of Skin Disease in Patients With Diffuse Cutaneous Systemic Sclerosis [J].
Rice, Lisa M. ;
Ziemek, Jessica ;
Stratton, Eric A. ;
McLaughlin, Sarah R. ;
Padilla, Cristina M. ;
Mathes, Allison L. ;
Christmann, Romy B. ;
Stifano, Giuseppina ;
Browning, Jeffrey L. ;
Whitfield, Michael L. ;
Spiera, Robert F. ;
Gordon, Jessica K. ;
Simms, Robert W. ;
Zhang, Yuqing ;
Lafyatis, Robert .
ARTHRITIS & RHEUMATOLOGY, 2015, 67 (11) :3004-3015
[54]   Anatomic demarcation by positional variation in fibroblast gene expression programs [J].
Rinn, John L. ;
Bondre, Chanda ;
Gladstone, Hayes B. ;
Brown, Patrick O. ;
Chang, Howard Y. .
PLOS GENETICS, 2006, 2 (07) :1084-1096
[55]   Altered Immune Phenotype in Peripheral Blood Cells of Patients with Scleroderma-Associated Pulmonary Hypertension [J].
Risbano, Michael G. ;
Meadows, Christina A. ;
Coldren, Christopher D. ;
Jenkins, Tiffany J. ;
Edwards, Michael G. ;
Collier, David ;
Huber, Wendy ;
Mack, Douglas G. ;
Fontenot, Andrew P. ;
Geraci, Mark W. ;
Bull, Todd M. .
CTS-CLINICAL AND TRANSLATIONAL SCIENCE, 2010, 3 (05) :210-218
[56]  
Seibold J., 2005, KELLEYS TXB RHEUMATO, V7th, P1279
[57]   X chromosome gene methylation in peripheral lymphocytes from monozygotic twins discordant for scleroderma [J].
Selmi, C. ;
Feghali-Bostwick, C. A. ;
Lleo, A. ;
Lombardi, S. A. ;
De Santis, M. ;
Cavaciocchi, F. ;
Zammataro, L. ;
Mitchell, M. M. ;
LaSalle, J. M. ;
Medsger, T., Jr. ;
Gershwin, M. E. .
CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2012, 169 (03) :253-262
[58]  
Shirahama Ryutaro, 2010, Allergology International, V59, P409, DOI 10.2332/allergolint.10-OA-0176
[59]   The Circulating Cell-free microRNA Profile in Systemic Sclerosis Is Distinct from Both Healthy Controls and Systemic Lupus Erythematosus [J].
Steen, Samantha O. ;
Iversen, Line V. ;
Carlsen, Anting Liu ;
Burton, Mark ;
Nielsen, Christoffer T. ;
Jacobsen, Soren ;
Heegaard, Niels H. H. .
JOURNAL OF RHEUMATOLOGY, 2015, 42 (02) :214-221
[60]   Classification Analysis of the Transcriptosome of Nonlesional Cultured Dermal Fibroblasts From Systemic Sclerosis Patients With Early Disease [J].
Tan, Filemon K. ;
Hildebrand, Bernard August ;
Lester, Malisa S. ;
Stivers, David N. ;
Pounds, Stanley ;
Zhou, Xiaodong ;
Wallis, Debra D. ;
Milewicz, Dianna M. ;
Reveille, John D. ;
Mayes, Maureen D. ;
Jin, Li ;
Arnett, Frank C., Jr. .
ARTHRITIS AND RHEUMATISM, 2005, 52 (03) :865-876