microRNA-29b: an Emerging Player in Human Cancer

被引：22
作者：
Liu, Hao
Wang, Bin
Lin, Jie
Zhao, Liang [1 ]
机构：
[1] Southern Med Univ, Nanfang Hosp, Dept Pathol, Guangzhou, Guangdong, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2014年 / 15卷 / 21期
关键词：
microRNAs; gene expression; tumor suppressor; gene therapy; EPITHELIAL-MESENCHYMAL TRANSITION; CHRONIC LYMPHOCYTIC-LEUKEMIA; TUMOR MICROENVIRONMENT; POTENTIAL BIOMARKERS; CELL-PROLIFERATION; PROGNOSTIC MARKER; MULTIPLE-MYELOMA; MESSENGER-RNAS; LUNG-CANCER; MIR-29B;
D O I：
10.7314/APJCP.2014.15.21.9059
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
MicroRNAs (miRNAs) are ubiquitously expressed small, non-coding RNAs that negatively regulate gene expression at a post transcriptional/translational level. They have emerging as playing crucial roles in cancer at all stages ranging from initiation to metastasis. As a tumor suppressor miRNA, aberrant expression of microRNA-29b (miR-29b) has been detected in various types of cancer, and its disturbance is related with tumor development and progression. In this review, we summarize the latest findings with regard to the tumor suppressor signatureof miR-29b and its regulatory mechanisms. Our review highlights the diverse relationships between miR-29b and its target genes in malignant tumors.
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收藏
页码：9059 / 9064
页数：6
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