Inhibition of oxidative stress in vivo through enzyme-like activity of carbon dots

被引：50

作者：

Dong, Chen ^{[1
]}

Wang, Shuna ^{[1
]}

Ma, Menghui ^{[1
]}

Wei, Peifa ^{[1
]}

Chen, Yan ^{[1
]}

Wu, Aiguo ^{[2
,3
]}

Zha, Zhengbao ^{[4
]}

Bi, Hong ^{[1
]}

机构：

[1] Anhui Univ, Sch Chem & Chem Engn, Anhui Key Lab Modern Biomfg, Key Lab Environm Friendly Polymer Mat Anhui Prov, Hefei 230601, Anhui, Peoples R China

[2] Chinese Acad Sci, Ningbo Inst Mat Technol & Engn,CAS Key Lab Magnet, Int Cooperat Base Biomed Mat Technol & Applicat, Zhejiang Engn Res Ctr Biomed Mat,Cixi Inst Biomed, Ningbo 315201, Zhejiang, Peoples R China

[3] Guangdong Lab, Adv Energy Sci & Technol, Huizhou 516003, Peoples R China

[4] Hefei Univ Technol, Sch Food & Biol Engn, Hefei 230009, Anhui, Peoples R China

来源：

APPLIED MATERIALS TODAY | 2021年 / 25卷

基金：

国家重点研发计划;

关键词：

Carbon dots; Oxidative stress; Enzyme-like; Reactive oxygen species; Anti-aging; QUANTUM DOTS; FREE-RADICALS; NANODOTS;

D O I：

10.1016/j.apmt.2021.101178

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Oxidative stress is a huge challenge to human health, and effective agents for resisting this adverse ef-fect are remains limited recently. Here, an excellent enzyme-like activity of carbon dots (e-CDs) via a facile solvothermal method is reported. In addition, e-CDs exert protective effects in HUVEC cell model by decreasing apoptosis. e-CDs also efficiently diminish ROS and apoptosis damage in mice treated with D-galactose. Furthermore, e-CDs-pretreated mice shows decrease apoptotic proteins in the brain and liver, confirming that e-CDs ameliorate D-galactose induced aging. Compared with general nanozymes, biocom-patible e-CDs demonstrate their high potential for anti-aging by the inhibition of oxidative stress. (c) 2021 Elsevier Ltd. All rights reserved.

引用

页数：7

共 44 条

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