The potential of biomarkers of fibrosis in chronic lung allograft dysfunction

被引：2
作者：
van der Ploeg, Eline A. [1 ]
Melgert, Barbro N. [2 ,3 ]
Burgess, Janette K. [3 ,4 ]
Gan, C. Tji [1 ]
机构：
[1] Univ Groningen, Univ Med Ctr Groningen, Dept Pulm Med, POB 30 001, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen, Groningen Res Inst Pharm, Dept Mol Pharmacol, POB 196, NL-9700 AD Groningen, Netherlands
[3] Univ Groningen, Univ Med Ctr Groningen, Groningen Res Inst Asthma & COPD GR1AC, POB 30-001, NL-9700 RB Groningen, Netherlands
[4] Univ Groningen, Univ Med Ctr Groningen, Dept Pathol & Med Biol, POB 30-001, NL-9700 RB Groningen, Netherlands
来源：
TRANSPLANTATION REVIEWS | 2021年 / 35卷 / 03期
关键词：
Lung transplantation; CLAD; BOS; RAS; Biomarker; Fibrosis; BRONCHIOLITIS-OBLITERANS-SYNDROME; IDIOPATHIC PULMONARY-FIBROSIS; SERUM KL-6; MATRIX METALLOPROTEINASES; EXTRACELLULAR-MATRIX; PROSTAGLANDIN E-2; CHRONIC REJECTION; TISSUE INHIBITOR; YKL-40; LEVELS; RISK-FACTORS;
D O I：
10.1016/j.trre.2021.100626
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Chronic lung allograft dysfunction (CLAD) is the major long-term cause of morbidity and mortality after lung transplantation. Both bronchiolitis obliterans syndrome and restrictive lung allograft syndrome, two main types of CLAD, lead to fibrosis in either the small airways or alveoli and pleura. Pathological pathways in CLAD and other types of fibrosis, for example idiopathic pulmonary fibrosis, are assumed to overlap and therefore fibrosis biomarkers could aid in the early detection of CLAD. These biomarkers could help to differentiate between different phenotypes of CLAD and could, in comparison to biomarkers of inflammation, possibly distinguish an infectious event from CLAD when a decline in lung function is present. This review gives an overview of known CLAD specific biomarkers, describes new promising fibrosis biomarkers currently investigated in other types of fibrosis, and discusses the possible use of these fibrosis biomarkers for CLAD. (c) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
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页数：11
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