The effect of induced hyperthermia on the immune system

被引：31

作者：

Dieing, Annette

Ahlers, Olaf

Hildebrandt, Bert

Kerner, Thoralf

Tamm, Ingo

Possinger, Kurt

Wust, Peter

机构：

[1] Univ Med Berlin, Dept Hematol & Oncol, D-10117 Berlin, Germany

[2] Univ Med Berlin, Charite Med Sch, Dept Anesthesiol & Intens Care Med, D-13353 Berlin, Germany

[3] Univ Med Berlin, Charite Med Sch, Dept Hematol & Oncol, Med Clin, D-13353 Berlin, Germany

[4] Univ Med Berlin, Charite Med Sch, Dept Radiat Med, D-13353 Berlin, Germany

来源：

NEUROBIOLOGY OF HYPERTHERMIA | 2007年 / 162卷

关键词：

whole-body hyperthermia; apoptosis; lymphocytes; cytokines; heat shock proteins; stress; review;

D O I：

10.1016/S0079-6123(06)62008-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Therapeutical hyperthermia has been considered for cancer therapy since William Coley observed tumour remission after induction of fever by bacterial toxins at the end of the 19th century. Because fever is associated with a variety of immunological reactions, it has been suspected, that therapeutical hyperthermia might also activate the immune system in a reproducible manner and thereby positively influence the course of the disease. During the last decade, new insight has been gained regarding the immunological changes taking place during therapeutic hyperthermia. In this chapter, we review the most relevant data known about the effect of hyperthermia on the immune system with special focus on alterations induced by therapeutical whole-body hyperthermia (WBH) in cancer patients.

引用

页码：137 / 152

页数：16

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