Total synthesis of aspinolide B: a ring-closing metathesis approach

被引：21

作者：

Ghosh, Subhash ^{[1
]}

Rao, R. Vengal ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 39期

关键词：

aspinolide B; ring-closing metathesis; D-Mannitol;

D O I：

10.1016/j.tetlet.2007.07.176

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly convergent stereoselective total synthesis of aspinolide B, a 10-membered lactone is described. The key step includes a ring-closing metathesis reaction to construct the 10-membered ring and the E-olefinic Moiety. D-Mannitol was used as a chiral pool material for the construction of the key fragments-the olefinic acid and the olefinic alcohol moieties. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：6937 / 6940

页数：4

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