Total synthesis of aspinolide B: a ring-closing metathesis approach

被引：21
作者：
Ghosh, Subhash [1 ]
Rao, R. Vengal [1 ]
机构：
[1] Indian Inst Chem Technol, Hyderabad 500007, Andhra Pradesh, India
来源：
TETRAHEDRON LETTERS | 2007年 / 48卷 / 39期
关键词：
aspinolide B; ring-closing metathesis; D-Mannitol;
D O I：
10.1016/j.tetlet.2007.07.176
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A highly convergent stereoselective total synthesis of aspinolide B, a 10-membered lactone is described. The key step includes a ring-closing metathesis reaction to construct the 10-membered ring and the E-olefinic Moiety. D-Mannitol was used as a chiral pool material for the construction of the key fragments-the olefinic acid and the olefinic alcohol moieties. (C) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：6937 / 6940
页数：4
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