Suzuki cross-coupling approaches to the synthesis of bioactive 3-substituted and 5-substituted-4-methoxy-6-methyl-2-pyrones

被引：38
|
作者：
Marrison, LR
Dickinson, JM
Fairlamb, IJS [1 ]
机构：
[1] Univ York, Dept Chem, York YO10 5DD, N Yorkshire, England
[2] Manchester Metropolitan Univ, Dept Chem & Mat, Manchester M1 5GD, Lancs, England
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 16期
关键词：
D O I：
10.1016/S0960-894X(03)00546-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Suzuki cross-coupling has been used to access a wide range of 3- and 5-substituted 2-pyrones, which show remarkable inhibitory activity against bacteria, yeasts and fungi. 3-Octenyl and 5-octenyl 2-pyrones inhibit human ovarium carcinoma (A2780) and human chronic myelogenous leukaemia (K562) cell lines at the micromolar level. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2667 / 2671
页数：5
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