Design, Synthesis, and Evaluation of Isoxazole-Thiadiazole Linked Carbazole Hybrids as Anticancer Agents

被引：24

作者：

Rao, B. V. Durga ^{[1
]}

Sreenivasulu, R. ^{[2
]}

Rao, M. V. Basaveswara ^{[1
]}

机构：

[1] Krishna Univ, Dept Chem, Machilipatnam 521001, Andhra Pradesh, India

[2] Jawaharlal Nehru Technol Univ, Univ Coll Engn Autonomous, Dept Chem, Kakinada 533003, Andhra Pradesh, India

来源：

RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2019年 / 89卷 / 10期

关键词：

ellipticine; cefozopram; carbazole; 1,2,4-thiadiazole; anticancer activity; ANTIPROLIFERATIVE ACTIVITY;

D O I：

10.1134/S1070363219100207

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A series of isoxazole-thiadiazole linked carbazole derivatives 12a-12j are synthesized and their chemical structures confirmed by H-1 and C-13 NMR and mass spectra. The products are tested for their anticancer activity against human cancer cell lines: MCF-7 (breast), A549 (lung), DU-145 (prostate), and MDA MB-231 (breast) by using MTT assay and etoposide as a reference drug. The accumulated data indicate that most of the compounds demonstrate anticancer activity higher than etoposide.

引用

页码：2115 / 2120

页数：6

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