microRNA deficiency in pancreatic islet cells exacerbates streptozotocin-induced murine autoimmune diabetes

被引：13

作者：

Mi, Qing-Sheng ^{[1
,2
,3
]}

He, Hong-Zhi ^{[1
,2
]}

Dong, Zheng ^{[4
]}

Isales, Carlos ^{[5
,6
]}

Zhou, Li ^{[1
,2
,3
]}

机构：

[1] Henry Ford Hlth Syst, Henry Ford Immunol Program, Detroit, MI USA

[2] Henry Ford Hlth Syst, Dept Dermatol, Detroit, MI USA

[3] Henry Ford Hlth Syst, Div Endocrinol Diabet Bone & Mineral Disorders, Dept Internal Med, Detroit, MI USA

[4] Med Coll Georgia, Dept Cellular Biol & Anat, Augusta, GA 30912 USA

[5] Med Coll Georgia, Dept Med, Augusta, GA 30912 USA

[6] Med Coll Georgia, Dept Orthoped Surg, Augusta, GA 30912 USA

来源：

CELL CYCLE | 2010年 / 9卷 / 15期

关键词：

dicer; microRNAs; type; 1; diabetes; beta cells; streptozotocin; BETA-CELLS; EXPRESSION; MELLITUS; MOUSE; MODEL;

D O I：

10.4161/cc.9.15.12596

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Recent studies have demonstrated that gene expression is regulated not only by protein-coding genes, but also by non-protein-coding small RNA molecules, microRNAs (miRNAs). miRNAs have emerged as important regulators involved in many biological processes, including cell proliferation and differentiation, apoptosis and metabolism and disease development. Here we report that specific miRNA deficiency in pancreatic islet cells exacerbates multiple low-dose streptozotocin-induced murine autoimmune type 1 diabetes, suggesting that miRNAs expressed in islet beta cells regulate their susceptibility to immune-mediated beta cell destruction.

引用

页码：3127 / 3129

页数：3

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