Solvent-free Williamson synthesis: An efficient, simple, and convenient method for chemoselective etherification of phenols and bisphenols

被引：33

作者：

Massah, Ahmad R.

Mosharafian, Masumeh

Momeni, Ahamad R.

Aliyan, Hamid

Naghash, H. Javaherian

机构：

[1] Islamic Azad Univ, Shahreza Branch, Dept Chem, Shahreza, Isfahan, Iran

[2] Islamic Azad Univ, Falavarjan Branch, Dept Chem, Falavarjan, Isfahan, Iran

来源：

SYNTHETIC COMMUNICATIONS | 2007年 / 37卷 / 11期

关键词：

chemoselective; bisphenols; etherification; phenols; solvent-free;

D O I：

10.1080/00397910701316268

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Etherification of phenols with dimethyl- and diethylsulfates and benzyl chloride was performed efficiently in the presence of a suitable solid base, NaHCO(3) or K(2)CO(3), under solvent-free conditions. The reaction proceeded rapidly at low temperature, and the corresponding ethers were obtained with high purity and excellent yield. Selective etherification of electron-poor phenols in the presence of electron-rich ones and also selective mono-etherification of bisphenols are the noteworthy advantages of this method. This method is environmentally friendly.

引用

页码：1807 / 1815

页数：9

共 30 条

[1] THE COPPER CATALYZED REACTION OF SODIUM METHOXIDE WITH ARYL BROMIDES - A MECHANISTIC STUDY LEADING TO A FACILE SYNTHESIS OF ANISOLE DERIVATIVES [J].