Diastereoselective Carbometalation of Oxa- and Azabicyclic Alkenes under Iron Catalysis

被引：70
作者：
Ito, Shingo [1 ,2 ]
Itoh, Takuma [1 ,2 ]
Nakamura, Masaharu [1 ,2 ]
机构：
[1] Kyoto Univ, Grad Sch Engn, Inst Chem Res, Int Res Ctr Elements Sci, Kyoto 6110011, Japan
[2] Kyoto Univ, Grad Sch Engn, Dept Energy & Hydrocarbon Chem, Kyoto 6110011, Japan
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2011年 / 50卷 / 02期
关键词：
bicyclic alkenes; carbometalation; diastereoselectivity; diphosphine ligands; iron; RING-OPENING REACTIONS; SECONDARY ALKYL-HALIDES; OXABICYCLIC ALKENES; GRIGNARD-REAGENTS; ENANTIOSELECTIVE DESYMMETRIZATION; ASYMMETRIC CYCLODIMERIZATION; UNSATURATED DICARBOXIMIDES; HYDROARYLATION; ALKENYLATION; LIGAND;
D O I：
10.1002/anie.201006180
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Highly diastereoselective carbometalation of oxa- and azabicyclic alkenes with arylzinc reagents has been achieved by using FeCl3 and novel ortho-phenylene diphosphine ligands (see scheme; E=electrophile). The carbozincation products are stable towards β-heteroatom elimination and can be trapped with various electrophiles. © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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收藏
页码：454 / 457
页数：4
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