A Narrative Review of Statin-Induced Rhabdomyolysis: Molecular Mechanism, Risk Factors, and Management

被引：29

作者：

Safitri, Nisa ^{[1
]}

Alaina, Maya Fadila ^{[1
]}

Pitaloka, Dian Ayu Eka ^{[1
,2
]}

Abdulah, Rizky ^{[1
,2
]}

机构：

[1] Univ Padjadjaran, Fac Pharm, Dept Pharmacol & Clin Pharm, Sumedang 45363, Indonesia

[2] Univ Padjadjaran, Ctr Excellence Higher Educ Pharmaceut Care Innova, Sumedang 45363, Indonesia

来源：

DRUG HEALTHCARE AND PATIENT SAFETY | 2021年 / 13卷

关键词：

statin; hypercholesterolemia; adverse effect; rhabdomyolysis; risk factor; SKELETAL-MUSCLE; THERAPY; SIMVASTATIN; PREVENTION; EXERCISE; ATORVASTATIN; CHOLESTEROL; INHIBITORS; TOXICITY; MYOPATHY;

D O I：

10.2147/DHPS.S333738

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Although statins are effective for treating hypercholesterolemia, they can have various side effects, including rhabdomyolysis, a potentially fatal condition. This review evaluated the incidence and underlying molecular mechanism of statin-induced rhabdomyolysis and analyzed its risk factors, prevention, and management. We focused on the clinical and randomized clinical trials of statin monotherapies and combinations with other drugs. The primary mechanism of statin therapy-induced rhabdomyolysis is believed to be a decrease in ubiquinone (coenzyme Q) produced by the HMG-CoA pathway. Additionally, different types of lipophilic and hydrophilic statins play a role in causing rhabdomyolysis. Although statin-induced rhabdomyolysis has a low incidence, there is no guarantee that patients will be free of this side effect. Rhabdomyolysis can be prevented by reducing the risk factors, such as using CYP3A4 inhibitors, using high-dose statins, and strenuous physical activities.

引用

页码：211 / 219

页数：9

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