Plasmodium falciparum multiplicity correlates with anaemia in symptomatic malaria

被引:15
作者
Mockenhaupt, FP
Ehrhardt, S
Eggelte, TA
Markert, M
Anemana, S
Otchwemah, R
Bienzle, U
机构
[1] Humboldt Univ, Med Fak Charite, Inst Trop Med, D-14050 Berlin, Germany
[2] Univ Amsterdam, Acad Med Ctr, Div Infect Dis Trop Med & AIDS, NL-1105 AZ Amsterdam, Netherlands
[3] Minist Hlth, Reg Hlth Adm, Takoradi, Ghana
[4] Univ Dev Studies, Sch Med & Hlth Sci, Tamale, Ghana
关键词
Plasmodium falciparum; msp; malaria; anaemia;
D O I
10.1046/j.1365-3156.2003.01117.x
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
In 366 Ghanaian children with symptomatic Plasmodium falciparum malaria, low haemoglobin levels and severe anaemia were associated with a high multiplicity of infection (MOI) and with distinct merozoite surface protein alleles. High MOI not only reflects premunition but may also contribute to anaemia in symptomatic malaria.
引用
收藏
页码:857 / 859
页数:3
相关论文
共 10 条
[1]  
[Anonymous], 1996, WHOMAL961077
[2]   Association of severe malaria with a specific Plasmodium falciparum genotype in French Guiana [J].
Ariey, F ;
Hommel, D ;
Le Scanf, C ;
Duchemin, JB ;
Peneau, C ;
Hulin, A ;
Sarthou, JL ;
Reynes, JM ;
Fandeur, T ;
Mercereau-Puijalon, O .
JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (02) :237-241
[3]   Multiplicity of Plasmodium falciparum infection in pregnancy [J].
Beck, S ;
Mockenhaupt, FP ;
Bienzle, U ;
Eggelte, TA ;
Thompson, WNA ;
Stark, K .
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2001, 65 (05) :631-636
[4]   Efficacy of chloroquine in the treatment of uncomplicated, Plasmodium falciparum malaria in northern Ghana [J].
Ehrhardt, S ;
Mockenhaupt, FP ;
Agana-Nsiire, P ;
Mathieu, A ;
Anemana, SD ;
Stark, K ;
Otchwemah, RN ;
Bienzle, U .
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY, 2002, 96 (03) :239-247
[5]   Complexity of Plasmodium falciparum infections is consistent over time and protects against clinical disease in Tanzanian children [J].
Färnert, A ;
Rooth, I ;
Svensson, Å ;
Snounou, G ;
Björkman, A .
JOURNAL OF INFECTIOUS DISEASES, 1999, 179 (04) :989-995
[6]   Impact of subpatent multi-species and multi-clonal plasmodial infections on anaemia in children from Nigeria [J].
May, J ;
Falusi, AG ;
Mockenhaupt, FP ;
Ademowo, OG ;
Olumese, PE ;
Bienzle, U ;
Meyer, CG .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2000, 94 (04) :399-403
[7]   Malaria-related anaemia [J].
Menendez, C ;
Fleming, AF ;
Alonso, PL .
PARASITOLOGY TODAY, 2000, 16 (11) :469-476
[8]  
Smith T, 1999, T ROY SOC TROP MED H, V93, pS59
[9]   Biased distribution of msp1 and msp2 allelic variants in Plasmodium falciparum populations in Thailand [J].
Snounou, G ;
Zhu, XP ;
Siripoon, N ;
Jarra, W ;
Thaithong, S ;
Brown, KN ;
Viriyakosol, S .
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1999, 93 (04) :369-374
[10]   Blood and bone marrow changes in malaria [J].
Wickramasinghe, SN ;
Abdalla, SH .
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2000, 13 (02) :277-299