Meta-analysis reveals a specific association of the PNPLA3 I148M polymorphism with ALT level in adolescents

被引：1
作者：
Liu, Zhengtao [1 ,2 ,3 ,4 ]
Ning, Huaijun [5 ]
He, Xiaoyin [5 ]
Que, Shuping [5 ]
Zhou, Lin [1 ,2 ,3 ,4 ]
机构：
[1] Zhejiang Univ, Affiliated Hosp 1, Dept Surg, Div Hepatobiliary & Pancreat Surg,Sch Med, Hangzhou, Zhejiang, Peoples R China
[2] Minist Publ Hlth, Key Lab Combined Multiorgan Transplantat, Hangzhou, Zhejiang, Peoples R China
[3] Key Lab Organ Transplantat Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China
[4] Collaborat Innovat Ctr Diag & Treatment Infect Di, Hangzhou, Zhejiang, Peoples R China
[5] Women & Childrens Hosp Guangxi, Dept Pediat, Nanning, Peoples R China
来源：
PERSONALIZED MEDICINE | 2015年 / 12卷 / 02期
关键词：
alanine aminotransferase; meta-analysis; patatin-like phospholipase domain containing 3; systematic review; FATTY LIVER-DISEASE; GENOME-WIDE ASSOCIATION; SERUM ALANINE AMINOTRANSFERASE; BODY-MASS INDEX; GENE VARIANT; INSULIN-RESISTANCE; POPULATION; PREVALENCE; SEVERITY; SUSCEPTIBILITY;
D O I：
10.2217/PME.14.72
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim: To evaluate potential link between the PNPLA3 rs738409 polymorphism and alanine aminotransferase (ALT) levels through an evidence-based study. Materials & Methods: Electronic literature databases, including PubMed, Embase and the Institute for Scientific Information, were searched for relevant studies. Pooling standardized mean differences for quantitative variables and summary odds ratios (OR) were respectively calculated using per-allele comparison. Results: Although a genotype-phenotype association was inconsistent in adults, this genetic effect was stable in adolescents. There was an approximate increase of 23% in ALT value, and 1.99-fold higher ALT elevation per risk allele increase with low heterogeneity. Conclusion: The PNPLA3 rs738409 polymorphism can have a differentiated influence on ALT level. Our meta-analysis provides reference data for the adjustment of diverse susceptibility due to the rs738409 polymorphism when evaluating liver injury in various populations.
引用
收藏
页码：67 / 82
页数：16
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