Impact of non-alcoholic fatty liver disease on the risk of sarcopenia: a nationwide multicenter prospective study

被引：30

作者：

Roh, Eun ^{[1
]}

Hwang, Soon Young ^{[2
]}

Yoo, Hye Jin ^{[1
]}

Baik, Sei Hyun ^{[1
]}

Lee, Jin-Hee ^{[3
]}

Son, Sang Joon ^{[4
]}

Kim, Hyeon Ju ^{[5
]}

Park, Yong Soon ^{[6
]}

Lee, Sam-Gyu ^{[7
]}

Cho, Be Long ^{[8
]}

Jang, Hak Chul ^{[9
]}

Kim, Bong Jo ^{[10
]}

Kim, Miji ^{[11
]}

Won, Chang Won ^{[12
]}

Choi, Kyung Mook ^{[1
]}

机构：

[1] Korea Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, Seoul, South Korea

[2] Korea Univ, Dept Biostat, Coll Med, Seoul, South Korea

[3] Catholic Univ Korea, Catholic Inst U Healthcare, Seoul, South Korea

[4] Ajou Univ, Dept Psychiat, Sch Med, Suwon, South Korea

[5] Jeju Natl Univ, Dept Family Med, Sch Med, Jeju, South Korea

[6] Hallym Univ, Dept Family Med, Chuncheon Sacred Heart Hosp, Chunchon, South Korea

[7] Chonnam Natl Univ, Dept Phys & Rehabil Med, Med Sch, Gwangju, South Korea

[8] Seoul Natl Univ, Ctr Hlth Promot & Optimal Aging, Dept Family Med, Coll Med, Seoul, South Korea

[9] Seoul Natl Univ, Dept Internal Med, Bundang Hosp, Seongnam, South Korea

[10] Gyeongsang Natl Univ, Dept Psychiat, Coll Med, Jinju, South Korea

[11] Kyung Hee Univ, East West Med Res Inst, Seoul, South Korea

[12] Kyung Hee Univ, Coll Med, Dept Family Med, Seoul, South Korea

来源：

HEPATOLOGY INTERNATIONAL | 2022年 / 16卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Muscle; Skeletal; Muscle strength; Sarcopenia; Nonalcoholic fatty liver disease; Cohort; INSULIN-RESISTANCE; ASSOCIATION; STRENGTH; OBESITY; HEALTH;

D O I：

10.1007/s12072-021-10258-8

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and aims Despite the association between sarcopenia and non-alcoholic fatty liver disease (NAFLD), no study has evaluated the predictive role of NAFLD in sarcopenia. We investigated impact of NAFLD on the risk of low muscle mass (LMM) and low muscle strength (LMS) in a nationwide multicenter study. Methods A total of 1595 community-dwelling people aged 70-84 years were followed for 2 years in the Korean Frailty and Aging Cohort Study. Muscle mass was estimated by dividing appendicular skeletal muscle mass (ASM) by body mass index (BMI). Muscle strength was measured as handgrip strength (HGS) divided by BMI. The sex-specific lowest quintiles of ASM/BMI and HGS/BMI of the study population were used as cutoffs for LMM and LMS, respectively. The risk of LMM and LMS were assessed according to hepatic steatosis index (HSI) and fatty liver index (FLI) quartiles. Results As HSI quartiles increased, the LMM risk increased gradually, after adjusting for age, sex, lifestyle factors, comorbidities, and several causative factors (insulin resistance, inflammation, and vitamin D) (Q4 vs. Q1 OR [95% CI] 3.46 [2.23-5.35]). The increased risk of LMS was even higher according to HSI quartiles (Q4 vs. Q1 5.81 [3.67-9.21]). Multivariate analyses based on FLI showed similar results. People with NAFLD (HSI> 36) were at higher risk of developing LMM and LMS compared to those without (1.65 [1.19-2.31] and 2.29 [1.61-3.26], respectively). Conclusions The presence of NAFLD may predict future risk of LMM and LMS, with greater impact on LMS than on LMM. [GRAPHICS] .

引用

页码：545 / 554

页数：10

共 31 条

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