Nonantioxidant functions of α-tocopherol in smooth muscle cells

被引：53

作者：

Azzi, A ^{[1
]}

Breyer, I ^{[1
]}

Feher, M ^{[1
]}

Ricciarelli, R ^{[1
]}

Stocker, A ^{[1
]}

Zimmer, S ^{[1
]}

Zingg, JM ^{[1
]}

机构：

[1] Inst Biochem & Mol Biol, CH-3012 Bern, Switzerland

来源：

JOURNAL OF NUTRITION | 2001年 / 131卷 / 02期

关键词：

tocotrienols; tocopherols; cell signaling; alpha-tocopherol binding protein;

D O I：

10.1093/jn/131.2.378S

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Most tocopherols and tocotrienols, with the exception of alpha -tocopherol, are not retained by humans. This suggests that alpha -tocopherol is recognized uniquely; therefore, it may exert an exclusive function. alpha -Tocopherol possesses distinct properties that are independent of its prooxidant, antioxidant or radical-scavenging ability. alpha -Tocopherol specifically inhibits protein kinase C, the growth of certain cells and the transcription of the CD36 acid collagenase genes. Activation events have also been seen on the protein phosphatase 2A (PP(2)A) and on the expression of other genes (alpha -tropomyosin and connective tissue growth factor). Neither beta -tocopherol nor probucol possessed the same specialty functions as alpha -tocopherol. Recently, we isolated a new ubiquitous cytosolic alpha -tocopherol binding protein (TAP). Its motifs suggest that it is a member of the hydrophobic ligand-binding protein family (CRAL-TRIO). TAP may also be involved in the regulation of cellular alpha -tocopherol concentration and alpha -tocopherol-mediated signaling.

引用

页码：378S / 381S

页数：4

共 60 条

[51] d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties [J].