Testicular carcinoma in situ in subfertile Danish men

被引:34
作者
Olesen, Inge A.
Hoei-Hansen, Christina E.
Skakkebaek, Niels E.
Petersen, Jorgen H.
Meyts, Ewa Rajpert-De
Jorgensen, Niels
机构
[1] Rigshosp, Univ Dept Growth & Reprod, Sect GR 5064, DK-2100 Copenhagen, Denmark
[2] Univ Copenhagen, Dept Biostat, Copenhagen, Denmark
来源
INTERNATIONAL JOURNAL OF ANDROLOGY | 2007年 / 30卷 / 04期
关键词
CIS; carcinoma in situ testis; IGCN; intratubular germ cell neoplasia; male infertility; prevalence; testicular biopsy; testicular cancer;
D O I
10.1111/j.1365-2605.2007.00798.x
中图分类号
R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
摘要
Carcinoma in situ (CIS) testis is the precursor stage for the majority of testicular germ cell tumours (TGCT). Infertility is one of the conditions known to predispose to TGCT, but based on scarce existing data, the prevalence of CIS in this risk group was estimated at only approximately 1%. To establish more objective data, we investigated retrospectively the prevalence of CIS based on testicular biopsies performed in a well-defined group of subfertile males. We included 453 patients who had testicular biopsies performed for infertility reasons during 1995-2005 at the Copenhagen University Hospital (Rigshospitalet). Biopsies were evaluated by two experienced observers independently. CIS was detected in 10 individuals, of whom three had bilateral CIS, corresponding to a prevalence of 2.2% (95% CI 1.1-4.0%). This is greater than the estimated risk of 0.45% for the age- and birth cohort-matched general Danish population. All patients with CIS testis had severe oligozoospermia (<= 2.06 million/mL). We confirmed that a thorough examination of men suffering from subfertility/infertility can identify those with an increased risk for testicular neoplasia and recommend performing bilateral biopsies, especially in the subpopulation of men with atrophic testicles, severe oligozoospermia and/or irregular ultrasonic pattern of their testicles.
引用
收藏
页码:406 / 411
页数:6
相关论文
共 50 条
  • [21] Conservative management of small testicular tumors relative to carcinoma in situ prevalence
    Huyghe, E
    Soulie, M
    Escourrou, G
    Mieusset, R
    Plante, P
    Thonneau, P
    JOURNAL OF UROLOGY, 2005, 173 (03) : 820 - 823
  • [22] Developmental model for the pathogenesis of testicular carcinoma in situ:: genetic and environmental aspects
    Rajpert-De Meyts, E
    HUMAN REPRODUCTION UPDATE, 2006, 12 (03) : 303 - 323
  • [23] Re: Testicular Microlithiasis and Carcinoma In Situ Overview and Proposed Clinical Guideline
    Meuleman, Eric
    EUROPEAN UROLOGY, 2010, 57 (05) : 917 - 917
  • [24] Carcinoma in situ -from clinical observation to a paradigm shift for testicular carcinogenesis
    Toppari, Jorma
    INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 2013, 57 (2-4) : 221 - 223
  • [25] Diagnosis and management of testicular intraepithelial neoplasia (carcinoma in situ) - surgical aspects
    Dieckmann, KP
    Classen, J
    Loy, V
    APMIS, 2003, 111 (01) : 64 - 69
  • [26] The clinical and biologic significance of serum inhibins in subfertile men
    Mahmoud, AM
    Comhaire, FH
    Depuydt, CE
    REPRODUCTIVE TOXICOLOGY, 1998, 12 (06) : 591 - 599
  • [27] Apoptotic gene expression in potentially fertile and subfertile men
    Cavalcanti, M. C. O.
    Steilmann, C.
    Failing, K.
    Bergmann, M.
    Kliesch, S.
    Weidner, W.
    Steger, K.
    MOLECULAR HUMAN REPRODUCTION, 2011, 17 (07) : 415 - 420
  • [28] Seminal biomarkers and their correlations to semen parameters in subfertile men
    Gruhl, Sabrina Lasini
    Ho, Lee Mee
    Sim, Marris Yin Xuan
    Lee, Shaw Ni
    Yu, Su Ling
    Yong, Tze Tein
    Lim, Liqing Serene
    Rajesh, Hemashree
    EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY-X, 2023, 19
  • [29] Testicular Cancer in Infertile Men With and Without Testicular Microlithiasis: A Systematic Review and Meta-Analysis of Case-Control Studies
    Barbonetti, Arcangelo
    Martorella, Alessio
    Minaldi, Elisa
    D'Andrea, Settimio
    Bardhi, Dorian
    Castellini, Chiara
    Francavilla, Felice
    Francavilla, Sandro
    FRONTIERS IN ENDOCRINOLOGY, 2019, 10
  • [30] Glycoprotein fucosylation is increased in seminal plasma of subfertile men
    Olejnik, Beata
    Kratz, Ewa M.
    Zimmer, Mariusz
    Ferens-Sieczkowska, Miroslawa
    ASIAN JOURNAL OF ANDROLOGY, 2015, 17 (02) : 274 - 280